MiR‐219a‐2-3p suppresses cell proliferation and promotes apoptosis by targeting MDM2/p53 in pituitary adenomas cells

Figures & data

Figure 1. miR-219a-2-3p was down-regulated in pituitary adenomas cell lines.

Figure 2. Overexpression of miR-219a-2-3p suppressed the proliferation and promoted apoptosis of pituitary adenomas cells.

Figure 3. MDM2 is the direct target gene of miR-219a-2-3p.

Figure 4. Restoration of the expression of MDM2 can attenuate the effect of miR-219a-2-3p on proliferation, apoptosis and p53 expression in pituitary adenomas cells.

Figure 5. The schematic representation of possible mechanisms of miR-219a-2-3p in pituitary adenomas.

Data availability statement

The data described in this article are openly available in the Open Science Framework at DOI:10.17605/OSF.IO/TPA6U.