COHERE – strengthening cooperation within the Canadian government on radiation research

Figures & data

Figure 1. The objective (A) and structural framework of COHERE (B).

Figure 2. COHERE Research framework includes five main themes and contributes to Canadian guidance on radiation protection standards.

Table 1. The five research themes under the COHERE SRA.

Themes	[1] Cancer effects	[2] Non-cancer effects	[3] Globalized data sharing and consolidation	[4] Capacity building	[5] Epidemiological studies
Research-lines	Conduct mechanistic based studies to examine dose-response relationships and links to adverse outcomes		Develop expertise in the area of data management and interpretation	Test new technologies/approaches for identifying low dose- response effects	Link occupational data to cancer/mortality data
Priority Area	Lung cancer (radon), kidney cancer (uranium), organ-level cancers (tritium)	Cataracts (high and low linear energy transfer), kidney toxicity (uranium)	Adverse outcome pathway, systematic reviews, benchmark dose modeling	Optical spectroscopy, 3 D organoid models, stem cell regeneration, phenotypic assays, dosimetry, ‘omics’ technology	International pooled studies, uranium workers; nuclear energy workers
Benefits	Mechanistic understanding in the area of low dose radiation exposures
	Better communication of risk to Canadians including radiation workers and members of the public and Indigenous peoples
	Harmonization with efforts internationally
	Contributing to Canadian guidance on radiation protection standards