International expert group collaboration for developing an adverse outcome pathway for radiation induced leukemia

Figures & data

Table 1. The list of AOPs from AOP-wiki (aopwiki.org) that contain ionizing radiation as a stressor (assessed on 28 February 2022).

AOP number	AOP name	OECD status
293	Increased DNA damage leading to increased risk of breast cancer	Under Development
294	Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer	Under Development
296	Oxidative DNA damage leading to chromosomal aberrations and mutations	EAGMST Under Review
272	Deposition of energy leading to lung cancer	EAGMST Approved
298	Chronic reactive oxygen species leading to human treatment-resistant gastric cancer	EAGMST Under Review
216	Deposition of energy leading to population decline via oocyte apoptosis	open
238	Deposition of energy leading to population decline via ovarian follicle breakdown	open
386	Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis	open
387	Deposition of ionizing energy leading to population decline via mitochondrial dysfunction	open
388	Deposition of ionizing energy leading to population decline via programmed cell death	open
299	Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation	open
396	Deposition of ionizing energy leads to population decline via impaired meiosis	open
432	Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia	open

Figure 1. Conceptual diagram for AOP432 ‘Deposition of energy by ionizing radiation leading to Acute Myeloid Leukemia’.

Table 2. List of literature databases used and corresponding search terms.

Database	Search quarry	Date	Returned entries
Pubmed​	​(leukemia OR leukemia OR AML) AND ("ionizing radiation" OR "ionizing radiation" OR "alpha radiation" OR radon OR "gamma radiation" OR "X rays") NOT review	2022.01.05​	1944​
Web of science​	ALL=((leukemia OR leukemia OR AML) AND ("ionizing radiation" OR "ionizing radiation" OR "alpha radiation" OR radon OR "gamma radiation" OR "X rays") NOT Review) and Articles (Document Types)​	2022.01.10​	2030​
Scopus​	TITLE-ABS-KEY ( ( ionizing OR ionizing OR gamma OR particle OR x-ray ) AND radiation AND ( leukemia OR leukemia ) ) AND PUBYEAR > 1950 AND PUBYEAR < 2022 AND ( LIMIT-TO ( DOCTYPE , "ar" ) ) AND ( LIMIT-TO ( LANGUAGE , "English" ) ) AND ( LIMIT-TO ( SRCTYPE , "j" ) )​	2022.01.21​	3035​

Figure 2. PRISMA diagram showing current results of literature screen associating IR with AML.