Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension

Abstract

This study investigated associations between total isoflavones and their categories (daidzein, genistein, glycitein) intake and the risks for metabolic disorders. We used the data of 6786 Chinese adults from the Nutrition Health Atlas Project. We performed multiple logistic regression and restricted cubic spline models assessing the risks for metabolic disorders (non-alcoholic fatty liver disease (NAFLD), hyperlipidaemia, hypertension, diabetes and overweight/obesity) in each category of isoflavones. Higher total isoflavones, daidzein and genistein intake were inversely associated with NAFLD (p < .05). Higher total isoflavones, daidzein, genistein and glycitein intake were also inversely associated with hyperlipidaemia (p < .01) and hypertension (p < .01). Dose-response analyses revealed that total isoflavones, daidzein, genistein and glycitein intakes were associated with the risks of metabolic disorders in a nonlinear trend. In conclusion, total isoflavones, daidzein and genistein intake were inversely associated with NAFLD, hyperlipidaemia and hypertension. Glycitein was inversely associated with hyperlipidaemia and hypertension.

Keywords:

• Isoflavones
• hypertension
• hyperlipidaemia
• NAFLD
• public health data

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

All data sets are stored and accessible via the NHALP website (http://www.yyjy365.org/nhap/index.php/index/idqc.html). If researchers want to study these data, they could cite this article and apply directly in the website.

Author contributions

YS and RN designed the study; YS and RN designed and completed the diet survey and data sharing website; YW and LL collected the data; LW, XW, LL and XM conducted the research; XM, LW and YZ performed statistical analysis; XM, WL, YZ, YW, Justina and RN wrote the manuscript. CY, YS and RN had primary responsibility for the final content. All authors read and approved the final manuscript.

Additional information

Funding

This work was supported by the National Natural Science Fund of China under Grant numbers [81872616, 81573133].