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International Journal of Polymer Analysis and Characterization Volume 24, 2019 - Issue 8
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Articles

Multi-level collagen aggregates and their applications in biomedical applications

Weihua DanKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, P.R. China; View further author information
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Yining ChenKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, P.R. China; View further author information
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Nianhua DanKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, P.R. China; Correspondence[email protected]
View further author information
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Xin ZhengKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, P.R. China; View further author information
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Lu WangKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, P.R. China; View further author information
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Changkai YangKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, P.R. China; ORCID Iconhttp://orcid.org/0000-0002-2062-9127View further author information
ORCID Icon,
Yanping HuangKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, P.R. China; View further author information
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Xinhua LiuKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi’anChina; View further author information
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Yang HuKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu, P.R. China; ;Key Laboratory of Environment Correlative Dietology, Ministry of Education, Huazhong Agricultural University, Wuhan, P.R. ChinaView further author information
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Pages 667-683 | Received 08 Aug 2019, Accepted 10 Aug 2019, Published online: 20 Aug 2019
 
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Abstract

In this review, the system of multi-level collagen aggregates including collagen molecular, collagen fiber, advanced collagen aggregates, and tissues was reviewed. The preparation methods of multi-level collagen aggregates were introduced, and the relationship between structure and properties of them was analyzed and clarified. The general rule of structure-activity relationship of multi-level collagen aggregates under different modifiers and modified conditions was analyzed, and a theoretical basis for the application of multi-level collagen aggregates in biomedical field was provided. Finally, the applications of a series of biomedical materials of multi-level collagen aggregates and their modified products were listed. It is confirmed that the application field of multi-level collagen aggregates and their modified products might be far greater than collagen and other biomass. The multi-level collagen aggregates might have a very broad application prospect.

Additional information

Funding

This research was supported by the National Natural Science Foundation of China [contract grant number 51473001], Open-end Fund of Fujian Key Laboratory of Leather Green Design and Manufacture [2018XYL02] and the Fundamental Research Funds for the Central Universities [20826041C4195].

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