Impact of serum immunoglobulins level and IL-18 promoter gene polymorphism among Egyptian patients with idiopathic thrombocytopenic purpura

Figures & data

Table 1 Demographic and clinical data of the 105 patients

Variables	Study group (n = 105)
Age (years)
Median (range)	22 (10–28)
Gender
Males; n (%)	25 (23.8)
Females; n (%)	80 (76.2)
Total leucocytic count (×10^9/l); median (range)	5 (3–9)
Hemoglobin concentration (g/dl); median (range)	9.5 (6–13)
Platelet count (×10^9/l); median (range)	22 (7–56)
ANA positive; n (%)	15 (14.3)
Anti-DNA positive; n (%)	10 (9.5)
LDH (IU/ml); median (range)	350 (250–550)
Fever/infection; n (%)	46 (88.5)
Bleeding manifestation; n (%)	79 (75.2)
IgA (mg/dl); median (range)	324 (146–501)
IgM (mg/dl); median (range)	82 (11–211)
IgG (mg/dl); median (range)	1592 (215–2248)

ANA, antinuclear antibodies; LDH, lactic dehydrogenase; Anti-DNA, anti-double-strand antibodies; IgA, immunoglobulin A; IgM, immunoglobulin M; IgG, immunoglobulin G.

Table 2 Variation in Igs median concentrations among the studied group

Variation in Igs median concentration	Studied group n (%)
IgA (mg/dl)
≤324 (median)	52 (49.5)
>324 (median)	53 (50.5)
IgM (mg/dl)
≤82 (median)	53 (50.5)
>82 (median)	52 (49.5)
IgG (mg/dl)
≤1592 (median)	52 (49.5)
>1592 (median)	53 (50.5)
Total	105

IgA, immunoglobulin A; IgM, immunoglobulin M; IgG, immunoglobulin G.

Table 3 The relation between IgA and response to standard treatment, bleeding tendency, and median platelet count

	Immunoglobulin A (mg/dl)
	IgA ≤ 324	IgA < 324	Total	P value
Response treatment
Responder	30	18	48	0.02
Non-responder	23	34	57
Bleeding manifestations
No	17	9	26	0.04
Yes	36	43	79
Platelet count
≤22.000	28	30	58	0.85
>22.000	25	22	47

Table 4 The relation between IgM and response to standard treatment, bleeding tendency, and median platelet count

	Immunoglobulin M (mg/dl)
	IgM ≤ 82	IgM < 82	Total	P value
Response treatment
Responder	19	29	48	0.05
Non-responder	33	24	57
Bleeding manifestations
No	9	17	26	0.068
Yes	43	36	79
Platelet count
≤22.000	34	24	58	0.03
>22.000	18	29	47

Table 5 The relation between IgG and response to standard treatment, bleeding tendency, and median platelet count

	Immunoglobulin G (mg/dl)
	IgG ≤ 1592	IgG > 1592	Total	P value
Response treatment
Responder	34	18	48	0.95
Non-responder	24	29	57
Bleeding manifestations
No	14	38	26	0.77
Yes	12	41	79
Platelet count
≤22.000/cmm	28	24	58	0.8
>22.000/cmm	30	23	47

Table 6 IL-18 promoter polymorphism in ITP patients and controls

Genotype frequency	ITP patients (n = 105)	Control group (n = 100)	P value
−607 genotype
CC	41 (39.0%)	40 (40%)	>0.05
AC	46 (43.8%)	46 (46%)	>0.05
AA	18 (17.1%)	14 (14%)	>0.05
CA + AA	64 (61.0%)	60 (60%)	>0.05

IL-18, interleukin 18.