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Articles

Impact of serum immunoglobulins level and IL-18 promoter gene polymorphism among Egyptian patients with idiopathic thrombocytopenic purpura

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References

  • Neunert C, Lim W, Crowther M, Cohen A, Solberg L, Crowther M. American Society of Hematology. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011;117(16):4190–207. doi: 10.1182/blood-2010-08-302984
  • Johnsen J. Pathogenesis in immune thrombocytopenia: new insights. Hematology. 2012;2012:306–12.
  • Ma L, Simpson E, Li J, Xuan M, Xu M, Baker L, et al. CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia. Blood. 2015;126(2):247–56. doi: 10.1182/blood-2015-03-635417
  • Wei Y, Hou M. T cells in the pathogenesis of immune thrombocytopenia. Semin Hematol. 2016;53(Suppl 1):S13–5. doi: 10.1053/j.seminhematol.2016.04.005
  • Shan NN, Zhu XJ, Peng J, Qin P, Zhuang XW, Wang HC, et al. Interleukin 18 and interleukin 18 binding protein in patients with idiopathic thrombocytopenic purpura. Br J Haematol. 2009;144(5):755–61. doi: 10.1111/j.1365-2141.2008.07520.x
  • Yazdanbakhsh K, Zhong H, Bao W. Immune dysregulation in immune thrombocytopenia. Semin Hematol. 2013;50(Suppl 1):S63–7. doi: 10.1053/j.seminhematol.2013.03.011
  • Boraschi D, Dinarello CA. IL-18 in autoimmunity: review. Eur Cytokine Netw. 2006;17:224–52.
  • Shan N, Zhu X, Wang Q, Wang C, Qin P, Peng J, et al. High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura. Haematologica. 2009;94:1603–7. doi: 10.3324/haematol.2009.007708
  • Shaheen IA, Botros SK, Morgan DS. Detection of expression of IL-18 and its binding protein in Egyptian pediatric immune thrombocytopenic purpura. Platelets. 2014;25(3):193–6. doi: 10.3109/09537104.2013.784734
  • Shan N, Hu Y, Hou M, Gao J, Wang X, Liu X, et al. Decreased Tim-3 and its correlation with Th1 cells in patients with immune thrombocytopenia. Thromb Res. 2014;133:52–56. doi: 10.1016/j.thromres.2013.10.029
  • Schroeder H, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010;125:41–52. doi: 10.1016/j.jaci.2009.09.046
  • Arnason J, Campigotto F, Neuberg D, Bussel B. Abnormalities in IgA and IgM are associated with treatment-resistant ITP. Blood. 2012;119:5016–20. doi: 10.1182/blood-2011-09-381020
  • Andersson J. Cytokines in idiopathic thrombocytopenic purpura (ITP). Acta Paediatr Suppl. 1998;424:61–64. doi: 10.1111/j.1651-2227.1998.tb01237.x
  • Semple JW, Milev Y, Cosgrave D, Mody M, Hornstein A, Blanchette V, et al. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood. 1996;87:4245–54.
  • Chaix J, Tessmer MS, Hoebe K, Fuseri N, Ryffel B, Dalod M, et al. Cutting edge: priming of NK cells by IL-18. J Immunol. 2008;3:1627–31. doi: 10.4049/jimmunol.181.3.1627
  • Gracie JA, Robertson SE, McInnes IB. Interleukin-18. J Leukocyte Biol. 2003;73:213–24. doi: 10.1189/jlb.0602313
  • Cortelazzo S, Finazzi G, Buelli M, Molteni A, Viero P, Barbui T. High risk of severe bleeding in aged patients with chronic idiopathic thrombocytopenic purpura. Blood. 1991;77(1):31–33.
  • Johnsen J. Pathogenesis in immune thrombocytopenia: new insights. Hematology. 2012;2012:306–12.
  • George J, Saucerman S. Platelet IgG, IgA, IgM, and albumin: correlation of platelet and plasma concentrations in normal subjects and in patients with ITP or dysproteinemia. Blood. 1988;72(1):362–5.
  • Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, et al. Complement is activated by IgG hexamers assembled at the cell surface. Science. 2014;343(6176):1260–3. doi: 10.1126/science.1248943
  • Beharka A, Paiva S, Leka L, Ribaya-Mercado J, Russell R, Nibkin Meydani S. Effect of age on the gastrointestinal-associated mucosal immune response of humans. J Gerontol A Biol Sci Med Sci. 2001;56(5):218–23. doi: 10.1093/gerona/56.5.B218
  • Cines D, Bussel J, Liebman H, Luning Prak E. The ITP syndrome: pathogenic and clinical diversity. Blood. 2009;113(26):6511–21. doi: 10.1182/blood-2009-01-129155
  • Giedraitis V, He B, Huang WX, Hillert J. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuroimmunol. 2001;112:146–52. doi: 10.1016/S0165-5728(00)00407-0
  • Smith AJ, Humphries SE. Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev. 2009;20:43–59. doi: 10.1016/j.cytogfr.2008.11.006
  • Zhao H, Zhang Y, Xiao G, Wu N, Xu J, Fang Z. Interleukin-18 gene promoter 607 A/C polymorphism and the risk of immune thrombocytopenia. Autoimmunity. 2014;47(7):478–81. doi: 10.3109/08916934.2014.921812
  • Li H, Xuan M, Xue F, Liu X, Zhang D, Fu R, et al. Absence of association of interleukin-18 gene polymorphisms with primary immune thrombocytopenia in a Chinese Han population. DNA Cell Biol. 2014;33(8):537–42. doi: 10.1089/dna.2013.2247

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