Cu@KF/Clinoptilolite Nanoparticles Promoted Green Synthesis of Pyrimidine Derivatives: Study of Antioxidant Activity

Abstract

The preparation of pyrrolo pyrimidinone derivatives were performed by using four component reactions of N-alkyl or aryl acetamides, dialkyloxalate, aldehydes, and guanidine in the presence of catalytic amounts of Cu@KF/CP NPs as a high performance catalyst in water at room temperature. In addition, for investigation of antioxidant ability radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product and catalyst.

Highlights

• The pyrimidine ring is an azaaromatic scaffold that can be found in many molecules of biological or pharmaceutical interest.

• multicomponent reactions (MCRs) are more interesting type of reaction due to mixing three or more reactants in one-pot and generating one product and economically useful and environmentally secure than to multi-step methods.

• Carrying out synthesis of organic compounds in water media is very interesting because of water is cheap solvent, more available with high amounts.

Keywords:

• ability of oxidation
• Cu@KF/CP
• DPPH radical trapping
• pyrimidine

Acknowledgment

We gratefully acknowledge from Azadshahr Branch, Islamic Azad University, Azadshahr, Iran because of spiritual support.

Disclosure statement

No potential conflict of interest was reported by the author(s).