Synthesis of Novel Acyclic Nucleoside Analogue Starting From 6-Aminouracil as Potent Antimicrobial Agent

Abstract

6-Aminouracil and 2-bromoethyl amine were prepared, as starting materials to be introduced as an alkylating reagent with sodium carbonate as a catalyst. Acyclic nucleoside was prepared for the first time, the expected structure of the final new compound 3 was determined based on IR, NMR, and mass spectroscopy, with safe and mild reaction conditions. The synthesized acyclic nucleoside has a potent and efficient antimicrobial activity compared to reference drugs particularly as an antibacterial agent, and can be used as an alternative to the commonly used antibiotics after performing the necessary biological research for its validation.

Graphical Abstract

Keywords:

• Synthesis
• 6-aminouracil
• bromoethylamine
• acyclic nucleoside analogues
• antimicrobial

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

Conceptualization: S.M.G.; Data curation: M.A., S.A., and S.A.O.; Formal analysis: M.A., S.A., S.M.G., and S.A.O.; Investigation: M.A., S.A., and S.A.O.; Methodology: M.A.; Project administration: M.A.; Writing—original draft: M.A. and S.M.G.; Writing—review and editing: S.A. and S.A.O. All authors have read and agreed to the published version of the manuscript.

Data availability statement

The data presented in this study are available in this article.

Additional information

Funding

This project was funded by Albaath University, Homs, Syria (Approval Number 956-05).