Review on Contemporary Synthetic Recipes to Access Versatile Coumarin Heterocycles

Abstract

Coumarin and its derivatives are extensively used as scaffolds in the synthesis of novel heterocyclic motifs. In the literature, several approaches especially involving metal and metal-free catalysts have been developed to get novel biological potential coumarin analogs. This review spotlights recent advancements in the synthesis of heterocyclic coumarin and its associated molecules recounting the literature articles from 2015 to the middle of 2022. Further, in this review, we have focused on the contents based on classical and non-classical methods for coumarin synthesis.

Graphical abstract

Keywords:

• Coumarins
• classical methods
• special recipes
• green synthesis
• synthetic methodology

Acknowledgments

The authors are grateful to Prof. Bennikallu Hire Mathada Mruthyunjayaswamy, Professor (Retd.), Department of Chemistry, Gulbarga University, Kalaburagi for his constant support and useful discussion.

Author contributions

Basavarajaiah S. M.: Conceptualization, methodology, software, data curation, writing—original draft preparation, visualization, investigation, software, validation, writing—reviewing and editing. Nagesh G. Y.: Writing—original draft preparation, visualization, investigation, software, validation, writing—reviewing and editing. Punith Kumar M.: Methodology, software, data curation, writing—original draft preparation. Rakesh B. M.: Data curation, Writing—original draft preparation and editing.

Disclosure statement

No potential conflict of interest was reported by the author(s).