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Critical Reviews in Food Science and Nutrition Volume 59, 2019 - Issue 19
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A next generation probiotic, Akkermansia muciniphila

Qixiao ZhaiState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; ;School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; ;International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu, China;
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Saisai FengState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; ;School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China;
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Narbad ArjanInternational Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu, China; ;Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, UK;
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Wei ChenState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; ;School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China; ;National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, China; ;Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, P.R. China; ;(Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou, ChinaCorrespondence[email protected]
Pages 3227-3236 | Received 08 May 2018, Accepted 27 Aug 2018, Published online: 29 Oct 2018
 
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Abstract

Akkermansia muciniphila, a symbiotic bacterium of the mucus layer, can utilize mucin as its sole carbon, nitrogen, and energy source. As an abundant resident in the intestinal tract of humans and animals, the probiotic effects of A. muciniphila including metabolic modulation, immune regulation and gut health protection, have been widely investigated. Various diseases such as metabolic syndromes and auto-immnue diseases have been reported to be associated with the disturbance of the abundance of A. muciniphila. In this review, we describe the biological characterization of A. muciniphia, the factors that influence its colonization of the intestinal tract; and discuss the current state of our knowledge on its role in host health and disease.

Acknowledgments

This work was supported by the National Natural Science Foundation of China Key Program (No. 31530056), National First-Class Discipline Program of Food Science and Technology (JUFSTR20180102) and the BBSRC Newton Fund Joint Centre Award.

Disclosure statement

The authors report no conflicts of interest.

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