https://orcid.org/0000-0003-0264-0290
Figures & data
Table 1. Instruments to identify the risk of malnutrition.
Table 2. Division of sirtuins based on Manjula, Anuja, and Alcain (Citation2020), Yan et al. (Citation2018), Wu et al. (Citation2018), Gao et al. (Citation2018).
Table 3. Biological functions of sirtuin 1 in the human body (authors’ own study).
Table 4. Sirtuin inhibitor compounds.
Table 5. Natural activators of sirtuins and their sources.
Table 6. Synthetic activators of sirtuins.
Figure 1. Shows the exact search terms used.
Figure 2. Flowchart of literature selection.
Figure 3. The pathomechanism of malnutrition and the effects of malnutrition on blood SIRT1 levels. Inadequate supply of food constituents contributes to the depletion of body reserves, which in turn leads to disruptions of physiological processes and disruptions of biochemical processes. These changes lead to minor symptoms of malnutrition, which lead to starvation of the uncomplicated simple depending on the diet. The uncomplicated simple hunger increases the expression of NAD+, which in turn increases the expression of SIRT1. However, the persistent depletion of the body’s reserves leads to more severe organ damage, which manifests itself in catabolism, protein loss in the body, fat loss, energy demand and glycogen loss in the body within 24 h. This leads to a decrease in the level of SIRT1 in the body. Unfavorable organ changes contribute to malnutrition, which can affect DRM + I, DRM − I, Malnutrition without disease, depending on the severity (DRM disease related malnutrition—ESPEN). Authors own study based on Bordone et al. (Citation2006); Cantó, Menzies, and Auwerx (Citation2015); Cederholm et al. (Citation2017); Chen et al. (Citation2008); McClain, Kirpich, and Smart (Citation2017); Nemoto, Fergusson, and Finkel (Citation2004).
Figure 4. Effect of SIRT1 in hepatic glycolipid metabolism under starvation. Authors’ own study based on Hallows, Yu, and Denu (Citation2012); Horton, Goldstein, and Brown (Citation2002); Purushotham et al. (Citation2009).
Figure 5. SIRT1 regulations in oxidative stress and inflammatory responses.
Figure 6. Possible factors that stimulate a decrease in SIRT1 expression in the body Degradation of SIRT1 by NAD + waste with simultaneous acetylation of NF-KB and ReIA/p65 and release of inflammatory mediators. Authors’ own study based on literature Abdelmohsen et al. (Citation2007).
Figure 7. SIRT1 as potential malnutrition biomarker (nucleus). Authors’ own study.
