One-pot synthesis of imidazo[1,2-α]pyridine thioethers using imidazo[1,2-α]pyridines, arylsulfonyl chlorides and hydrazine

Abstract

A one-pot reaction of making RS-substituted imidazo[1,2-α]pyridine derivatives by directly using aryl or alkylsulfonyl chloride and hydrazine was developed, selectively giving good yields of the expected products. Compared with previously reported methods of using ArSO₂NHNH₂ as a sulfur source, this method is much cheaper, more practical and convenient and enriches current methods to make thioether-containing compounds, providing a good example of green chemistry.

Graphical Abstract

Keywords:

• Imidazo[1,2-α]pyridine
• sulfenylation
• benzene sulfonylhydrazine
• hydrazine

Disclosure statement

There are no conflicts to declare.

Additional information

Funding

Aihua Zhou acknowledge Jiangsu University for financial support (1281290006).