Abstract
This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. In addition, several compounds caused cytotoxicity at high cell densities. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.
Graphical Abstract
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Acknowledgments
We gratefully acknowledge the financial support for NA and KF through the Office of Undergraduate Research at the University of West Florida. KF was supported by NIH grant T34GM110517. KF is grateful to NIH for support through the Institute of General Medical Sciences of the National Institutes of Health under grant number 1T34GM110517-01. This content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Disclosure statement
The authors report no potential conflict of interest.