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Research Article

Autonomic nervous system and endocrine system response to upper or lower cervical spine mobilization in males with persistent post-concussion symptoms: a proof-of-concept trial

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Received 16 Apr 2024, Accepted 29 May 2024, Published online: 21 Jun 2024

Figures & data

Figure 1. Timing of outcome measurement. During each intervention, sCOR concentrations and HRV data were collected in clinic at three timepoints, baseline or five-minutes prior to the intervention (pre-5), then five-minutes (post-5) and thirty-minutes (post-30) following the intervention. Baseline sCOR samples were collected at home on day five and six between the hours of 2200–0000 (baseline-pm). sCOR samples were then collected the night following the intervention between the hours of 2200–0000 (post-pm). HRV data was collected each morning on waking, at home, between the hours of 0600–0800. Day two to seven were baseline HRV data (baseline-am). Day eight was post-intervention HRV data (post-am). RPQ data was filled out at the same time as sCOR samples were collected on day six (baseline-pm) and seven (post-pm), and HRV data on day seven (baseline-am) and eight (post-am).

Figure 1. Timing of outcome measurement. During each intervention, sCOR concentrations and HRV data were collected in clinic at three timepoints, baseline or five-minutes prior to the intervention (pre-5), then five-minutes (post-5) and thirty-minutes (post-30) following the intervention. Baseline sCOR samples were collected at home on day five and six between the hours of 2200–0000 (baseline-pm). sCOR samples were then collected the night following the intervention between the hours of 2200–0000 (post-pm). HRV data was collected each morning on waking, at home, between the hours of 0600–0800. Day two to seven were baseline HRV data (baseline-am). Day eight was post-intervention HRV data (post-am). RPQ data was filled out at the same time as sCOR samples were collected on day six (baseline-pm) and seven (post-pm), and HRV data on day seven (baseline-am) and eight (post-am).

Figure 2. Flow of participants.

Figure 2. Flow of participants.

Table 1. Baseline participant characteristics (n = 19).

Table 2. Clinical measurements of salivary cortisol and rMSSD.

Table 3. Home measurements of salivary cortisol and rMSSD.

Table 4. RPQ scores.

Figure 3. Clinic measurement of salivary cortisol (figure includes 95% confidence interval error bars).

Figure 3. Clinic measurement of salivary cortisol (figure includes 95% confidence interval error bars).

Figure 4. Clinic measurement of rMSSD (figure includes 95% confidence interval error bars).

Figure 4. Clinic measurement of rMSSD (figure includes 95% confidence interval error bars).

Figure 5. Home measurement of salivary cortisol (figure includes 95% confidence interval error bars).

Figure 5. Home measurement of salivary cortisol (figure includes 95% confidence interval error bars).

Figure 6. Home measurement of rMSSD (figure includes 95% confidence interval error bars).

Figure 6. Home measurement of rMSSD (figure includes 95% confidence interval error bars).

Figure 7. RPQ score filled out at the same time as sCOR.

Figure 7. RPQ score filled out at the same time as sCOR.

Figure 8. RPQ score filled out at the same time as rMSSD.

Figure 8. RPQ score filled out at the same time as rMSSD.
Supplemental material

Supplemental Material

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Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.