Preparation and Evaluation of Fast Dissolving Ibuprofen-Polyethylene Glycol 6000 Solid Dispersions

Figures & data

FIG. 1 Structure of ibuprofen.

FIG. 2 Locally designed ointment formulation vessel.

FIG. 3 Scanning electron micrographs. (A). Ibuprofen, (B). Polyethylene glycol 6000, (C). 1:1 w/w physical mixtures. (D). 1:1 w/w solid dispersions, and (E). 1:10 w/w solid dispersions.

FIG. 4 Solubility of solid dispersions in phosphate buffer (pH 6.8). Data are expressed as mean ± SD (n = 3).

FIG. 5 Dissolution profiles of solid dispersions in phosphate buffer (pH 6.8). Data are expressed as mean ± SD (n = 3).

FIG. 6 Phase solubility behavior of ibuprofen at 25°C in polyethylene glycol 6000 solutions in phosphate buffer (pH 6.8). Data are expressed as mean ± SD (n = 3).

FIG. 7 Differential scanning calorimetric thermograms of ibuprofen, polyethylene glycol 6000, physical mixtures, and solid dispersions.

FIG. 8 Fourier transform infrared absorption spectra of ibuprofen, (top to bottom). 1:1 w/w solid dispersions, 1:10 w/w solid dispersions, polyethylene glycol 6000, and 1:1 w/w physical mixtures.

TABLE 1 Pharmacokinetic parameters of ibuprofen delivered by ibuprofen powder, ibuprofen-polyethylene glycol 6000 solid dispersions, and physical mixtures

Parameter	Ibuprofen	1:10 w/w PMs	2:1 w/w SDs	1: 1 w/w SDs
AUC(h. μ g/ml)	12.41 ± 8.46	61.49 ± 13.69	142.55 ± 45.79	322.86 ± 116.85
Tmax (h)	0.75 ± 0.18	0.59 ± 0.14	0.52 ± 0.15	0.30.30 ± 0.07
Cmax (μ g/ml)	5.31 ± 3.92	14.66 ± 3.02	50.39 ± 22.23	95.19 ± 48.46
Kel (h^− 1)	0.23 ± 0.07	0.18 ± 0.01	0.20 ± 0.06	0.19 ± 0.06
T½(h)	3.25 ± 1.01	3.86 ± 0.21	3.69 ± 0.17	4.01 ± 1.49

Data are expressed as mean ± SD (n = 5).

Each value represents the mean ± SD. (n = 5).

*p value < 0.0034 compared with powder ibuprofen.

FIG. 9 Plasma concentration-time profiles of ibuprofen after oral administration of ibuprofen powder, physical mixtures, and solid dispersions equivalent to 25 mg/kg ibuprofen in rats. Data are expressed as mean ± SD (n = 5).