Figures & data
Figure 2. Thiopental sodium (TS), in vitro release from solid lipid nanoparticles SLN) and TS- solution at different time intervals (0–24 h) in phosphate buffer (pH 7.4) with dialysis method.
![Figure 2. Thiopental sodium (TS), in vitro release from solid lipid nanoparticles SLN) and TS- solution at different time intervals (0–24 h) in phosphate buffer (pH 7.4) with dialysis method.](/cms/asset/15928b0f-8928-4556-aecb-f13c21e4eb40/idrd_a_1803449_f0002_c.jpg)
Table 1. Particle size, entrapment efficiency and loading capacity of SLN after storage at 25°C/60%RH.
Table 2. Particle size, entrapment efficiency and loading capacity of SLN after storage at 40°C/75%RH.
Figure 3. Exhibited the systolic blood pressure (SBP) in the normal and experimental group during the 8 weeks. Tail cuff method was used for the estimation of SBP. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.
![Figure 3. Exhibited the systolic blood pressure (SBP) in the normal and experimental group during the 8 weeks. Tail cuff method was used for the estimation of SBP. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.](/cms/asset/79efcf15-dde5-4999-bcbf-ee3a4fe82fe4/idrd_a_1803449_f0003_b.jpg)
Figure 4. Exhibited the level of hemodynamics parameters in the normal and experimental group during the 8 weeks. (a) LVSP, (b) LVEDP, (c) +dp/dtmax and (d) −dp/dtmax Date are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.
![Figure 4. Exhibited the level of hemodynamics parameters in the normal and experimental group during the 8 weeks. (a) LVSP, (b) LVEDP, (c) +dp/dtmax and (d) −dp/dtmax Date are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.](/cms/asset/cb53ae09-5ad6-449d-a3c5-598931a74d7d/idrd_a_1803449_f0004_b.jpg)
Figure 5. Exhibited the level of cardiac remodeling parameters in the normal and experimental group during the 8 weeks. (a) TAA, (b) LA, (c) CSA and (d) CSA/TAA. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.
![Figure 5. Exhibited the level of cardiac remodeling parameters in the normal and experimental group during the 8 weeks. (a) TAA, (b) LA, (c) CSA and (d) CSA/TAA. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.](/cms/asset/14abc2c1-5e0c-4390-a17d-b8f7faf3380c/idrd_a_1803449_f0005_b.jpg)
Figure 6. Exhibited the level of aortic parameters in the normal and experimental group during the 8 weeks. (a) Lumen, (b) Media, (c) M/L and (d) AR. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.
![Figure 6. Exhibited the level of aortic parameters in the normal and experimental group during the 8 weeks. (a) Lumen, (b) Media, (c) M/L and (d) AR. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.](/cms/asset/386c5157-05ca-45bd-9887-b4c07f51cacb/idrd_a_1803449_f0006_b.jpg)
Figure 7. Exhibited the level of biochemical parameters in the normal and experimental group during the 8 weeks. (a) NO, (b) L-arginine, (c) BH4 and (d) ET-1. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.
![Figure 7. Exhibited the level of biochemical parameters in the normal and experimental group during the 8 weeks. (a) NO, (b) L-arginine, (c) BH4 and (d) ET-1. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.](/cms/asset/eaec44a0-05a3-454a-994a-2d57295bb5ba/idrd_a_1803449_f0007_b.jpg)
Figure 8. Exhibited the level of antioxidant parameters in the normal and experimental group during the 8 weeks. (a) SOD, (b) CAT, (c) GSH-Px and (d) MDA. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.
![Figure 8. Exhibited the level of antioxidant parameters in the normal and experimental group during the 8 weeks. (a) SOD, (b) CAT, (c) GSH-Px and (d) MDA. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.](/cms/asset/e426eedd-e8ef-4851-a003-6b80781f146b/idrd_a_1803449_f0008_b.jpg)
Figure 9. Exhibited the level of apoptosis marker in the normal and experimental group during the 8 weeks. (a) caspase-3, (b) caspase-8 and (c) caspase-9. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.
![Figure 9. Exhibited the level of apoptosis marker in the normal and experimental group during the 8 weeks. (a) caspase-3, (b) caspase-8 and (c) caspase-9. Data are presented as the mean ± SD, *p < .05, **p < .01 and ***p < .001.](/cms/asset/b17b0541-33ec-49fd-a0ad-62266247f964/idrd_a_1803449_f0009_b.jpg)