Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

Figures & data

Figure 1. The mechanism of PLGA degradation.

Figure 2. Degradation mechanism of PLGA microspheres.

Figure 3. Chemical structure of poly(lactic-co-glycolic acid) and its monomers, and the synthesis of PLGA.

Figure 4. Adjusting the polymer to control the performance.

Figure 5. The preparation process of PLGA microspheres.

Figure 6. (A) Schematic of naltrexone-loaded PLGA generation using an in-line emulsification-extraction process. (B) Experimental set-up used to generate particles by pumping both oil- and aqueous-phases into the homogenizer and transferring the emulsion to the extraction solution (Sharifi et al., 2020).

Sharifi F, Otte A, Yoon G, et al. (2020). Continuous in-line homogenization process for scale-up production of naltrexone-loaded PLGA microparticles. J Control Release 325:347–58.

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