Figures & data
Figure 1. Histology of liver in rats toploading with NanoRBC (a), LactRing (b), SFHb (c), PolyHb (d), or RBC (e). Under light microscope, there was no abnormality in groups a, b, d, and e. For group c infused with SFHb there is Hb accumulation and steatmotosis. H&E staining, ×400.
![Figure 1. Histology of liver in rats toploading with NanoRBC (a), LactRing (b), SFHb (c), PolyHb (d), or RBC (e). Under light microscope, there was no abnormality in groups a, b, d, and e. For group c infused with SFHb there is Hb accumulation and steatmotosis. H&E staining, ×400.](/cms/asset/ba11a03f-eced-430e-a42a-2ab68a445584/ianb19_a_355590_f0001_b.gif)
Figure 2. Histology of spleen in rats toploading with NanoRBC (a), LactRing (b), SFHb (c), PolyHb (d), or RBC (e). No obvious abnormalities were seen in all groups. H&E staining, ×400.
![Figure 2. Histology of spleen in rats toploading with NanoRBC (a), LactRing (b), SFHb (c), PolyHb (d), or RBC (e). No obvious abnormalities were seen in all groups. H&E staining, ×400.](/cms/asset/894a6103-cc71-4128-88b2-3d93f47b18fa/ianb19_a_355590_f0002_b.gif)
Figure 3. 33% toploading of Nano artificial RBCs, LactRing, SFHb, PolyHb, or RBC does not result in elevation of the systemic levels of total bilirubin in rats. (Mean±S.E.).
![Figure 3. 33% toploading of Nano artificial RBCs, LactRing, SFHb, PolyHb, or RBC does not result in elevation of the systemic levels of total bilirubin in rats. (Mean±S.E.).](/cms/asset/14b7559a-fad0-45fb-95f0-48cff4d9b7d6/ianb19_a_355590_f0003_b.gif)
Figure 4. The albumin level for the Nano artificial RBCs group remained the highest of all the solutions infused. (Mean±S.E.).
![Figure 4. The albumin level for the Nano artificial RBCs group remained the highest of all the solutions infused. (Mean±S.E.).](/cms/asset/d8ded94c-c067-48e7-96ad-35eb7305d67f/ianb19_a_355590_f0004_b.gif)
Figure 5. There was no elevation of the systemic cholesterol level for the groups receiving 33% volume toploading of Nano artificial RBCs, LactRing, SFHb, PolyHb, or RBCs. (Mean±S.E.).
![Figure 5. There was no elevation of the systemic cholesterol level for the groups receiving 33% volume toploading of Nano artificial RBCs, LactRing, SFHb, PolyHb, or RBCs. (Mean±S.E.).](/cms/asset/29de9c8c-4da5-4a44-9200-b6c30917b07c/ianb19_a_355590_f0005_b.gif)
Figure 6. Creatine kinase levels in rats infused with 33% volume of Nano artificial RBCs, LactRing, SFHb, PolyHb, and RBCs. (Mean±S.E.).
![Figure 6. Creatine kinase levels in rats infused with 33% volume of Nano artificial RBCs, LactRing, SFHb, PolyHb, and RBCs. (Mean±S.E.).](/cms/asset/7b4c2617-96fb-4501-9f2a-78a6a29027f0/ianb19_a_355590_f0006_b.gif)
Figure 7. ALT levels in rats infused with 33% volume of Nano artificial RBCs, LactRing, SFHb, PolyHb, and RBCs. (Mean±S.E.).
![Figure 7. ALT levels in rats infused with 33% volume of Nano artificial RBCs, LactRing, SFHb, PolyHb, and RBCs. (Mean±S.E.).](/cms/asset/32f8f687-4c39-4151-87a1-e66bd666303a/ianb19_a_355590_f0007_b.gif)
Figure 8. AST levels in rats infused with 33% volume of Nano artificial RBCs, LactRing, SFHb, PolyHb, and RBCs. (Mean±S.E.).
![Figure 8. AST levels in rats infused with 33% volume of Nano artificial RBCs, LactRing, SFHb, PolyHb, and RBCs. (Mean±S.E.).](/cms/asset/9503d93c-2274-4f13-9b74-ea1bbc32ffbb/ianb19_a_355590_f0008_b.gif)