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Artificial Cells, Blood Substitutes, and Biotechnology Volume 36, 2008 - Issue 6
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Original

Long-term Effects on the Histology and Function of Livers and Spleens in Rats after 33% Toploading of PEG-PLA-nano Artificial Red Blood Cells

Zun Chang Liu Artificial Cells & Organs Research Centre, Departments of Physiology, Medicine & Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
&
Professor Thomas M.S. Chang Artificial Cells & Organs Research Centre, Departments of Physiology, Medicine & Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaCorrespondence[email protected]
Pages 513-524 | Published online: 11 Jul 2009

References

  • Chang, T.M.S. (1957). Hemoglobin corpuscles. Report of a research project of B.Sc. Honours Physiology, McGill University, 1–25, Medical Library, McGill University (also reprinted in J. Biomaterials, Artificial Cells and Artificial Organs 16:1–9, 1988).
  • Chang T.M.S. Semipermeable microcapsules. Science 1964; 146(3643)524
  • Chang T.M.S. Artificial Cells. Monograph. Charles C. Thomas, Springfield, IL 1972
  • Djordjevich L., Miller I.F. Synthetic erythrocytes from lipid encapsulated hemoglobin. Exp. Hematol 1980; 8: 584
  • Philips W.T., Klpper R.W., Awasthi V.D., Rudolph A.S., Cliff R., Kwasiborski V. V., Goins B.A. Polyethylene glyco-modified liposome-encapsulated Hb: a long circulating red cell substitute. J. Pharm. Exp. Therapeutics 1999; 288: 665–670
  • Kobayashi, K., Tsuchida, E., Horinouchi, H., eds. (2005). Artificial Oxygen Carriers, Springer-Verlag Publisher, MontrealCanada.
  • Chang T.M.S. Biodegradable semipermeable microcapsules containing enzymes, hormones, vaccines, and other biologicals. J Bioengineering 1976; 1: 25–32
  • Chang, T.M.S. , Yu, W.P. (1997). Biodegradable polymer membrane containing hemoglobin as potential blood substitutes. U.S.A. Patent 5670173, September 23.
  • Yu W.P., Chang T.M.S. Submicron biodegradable polymer membrane hemoglobin nanocapsules as potential blood substitutes: a preliminary report. Artificial Cells, Blood Substitutes and Immobilization Biotechnology, an International Journal 1994; 22: 889–894
  • Yu W.P., Chang T.M.S. Submicron biodegradable polymer membrane hemoglobin nanocapsules as potential blood substitutes. Artificial Cells, Blood Substitutes and Immobilization Biotechnology, An International Journal 1996; 24: 169–184
  • Chang T.M.S., Powanda D., Yu W.P. Ultrathin polyethylene-glycol-polylactide copolymer membrane nanocapsules containing polymerized Hb and enzymes as nano-dimension RBC substitutes. Artificial Cells, Blood Substitutes & Biotechnology, An International Journal 2003; 31: 231–248
  • Chang T.M.S. Therapeutic applications of polymeric artificial cells. Nature Review: Drug Discovery 2005; 4: 221–235
  • Chang T.M.S. Monograph on ARTIFICIAL CELLS: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative Medicine, Bioencapsulation, Cell/Stem Cell Therapy. World Science Publisher, Singapore 2007
  • Liu, Z.C. , Chang, T.M.S. (2008). Effects of PEG-PLA-nano artificial cells containing hemoglobin on kidney function and renal histology in rats. Artificial Cells, Blood Substitutes & Biotechnology, An International Journal 36: in press.

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