Anti-cholesterol triterpenoid acids from Saurauia vulcani Korth. (Actinidiaceae)

Figures & data

Figure 1. Chemical structures of compound 1–2.

Figure 2. Selected HMBC correlations of 1–2.

Table 1. NMR data (500 MHz for ¹H and 125 MHz for ¹³C in CDCl₃) for 1 and 2.

Position	1		2
	^13C NMR δC (mult.)	^13H NMR δH (integral, mult., J Hz)	^13C NMR δC (mult.)	^13H NMR δH (integral, mult., J Hz)
1	38.4	0.97 (1H; m); 1.55 (1H; m)	39.5	1.01 (2H; m)
2	27.2	1.52 (2H; m)	27.1	1.04 (2H; m)
3	77.7	3.17 (1H; dt,11.0; 3.9)	78.6	3.16 (1H; dd, 11.1; 4.5)
4	39.5	–	39.5	–
5	55.4	0.83 (1H; m)	56.3	0.83 (1H; m)
6	18.3	1.51 (1H; m); 1.42 (1H; m)	15.2	1.51 (2H; m)
7	33.1	1.33 (2H; t, 3.6)	33.9	1.33 (2H; t, 4.2)
8	39.2	–	40.7	–
9	47.7	1.53 (1H; m)	48.2	1.71 (1H; m)
10	36.9	–	37.9	–
11	23.3	1.13 (2H; m)	24.4	1.35 (2H; m)
12	122.2	5.21 (1H; t, 3.9)	128.9	5,27 (1H; t, 3.9)
13	144.2	–	139.7	–
14	41.6	–	42.3	–
15	27.6	1.50 (2H; m)	28.1	1.13 (2H; m)
16	23.2	1.53 (1H; m); 1.92 (1H;m)	26.5	1.53 (1H; m); 1.92 (1H;m)
17	42.0	–	48.0	–
18	41.4	2.90 (1dd; 9.7; 3.9)	54.5	2.64 (1H; td, 8.5, 4.5)
19	46.0	2.07 (2H; m)	73.2	–
20	30.4	–	42.3	–
21	33.6	1.60 (2H; m)	32.7	1.30 (2H; m)
22	33.1	1.30 (2H; m)	38.5	1.64 (1H; m); 1.73 (1H; m)
23	27.9	0.9 (3H; s)	29.4	0.98 (3H; s)
24	15.5	0.79 (3H; s)	15.9	0.79 (3H; s)
25	15.5	0.77 (3H; s)	16.4	0.94 (3H; s)
26	16.8	0.84 (3H; s)	17.4	0.84 (3H; s)
27	25.4	1.17 (3H; s)	24.7	1.68 (3H; s)
28	178.2	–	179.2	–
29	28.6	0.98 (3H; s)	27.3	1.13 (3H; s)
30	23.1	0.79 (3H; s)	16.7	0.95 (3H; d, 4.6)

Figure 3. The anti-cholesterol effects of the isolated compounds 1–2. The level of cholesterol was reduced in a dose-dependent manner. Cholesterol level of the untreated compound or negative control was calculated as 100%. All experiments were conducted in triplicate (n = 3) and compared with negative control. Standard deviation (SD) is indicated by error bars. ns: not significant, *p < .05, **p < .01, ***p < .001