Views

CrossRef citations to date

Altmetric

Original Article

Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS

Ilhami Gulcina Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, TurkeyCorrespondence[email protected] [email protected]

https://orcid.org/0000-0001-5993-1668

Ruya Kayaa Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkey;b Central Research and Application Laboratory, Agri Ibrahim Cecen University, Agri, Turkey

Ahmet C. Gorenc Department of Analytical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey;d Drug Application and Research Center, Bezmialem Vakif University, Istanbul, Turkey

Hulya Akincioglue Department of Chemistry, Faculty of Sciences and Arts, Agri Ibrahim Cecen University, Agri, Turkey

Meryem Topalf Vocational School of Health Services, Gumushane University, Gumushane, Turkey

Zeynebe Bingola Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkey

Kader Cetin Çakmaka Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkey

Sevim B. Ozturk Sarikayag Department of Food Engineering, Faculty of Engineering and Natural Sciences, Gumushane University, Gumushane, Turkey

Lokman Durmazh Department of Medical Services and Technology, Cayirli Vocational School, Erzincan Binali Yildirim University, Erzincan, Turkey

Saleh Alwaseli Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia

show all

Figures & data

Table 1. Validation and uncertainty parameters for antioxidant phenolic acids, LC-MS/MS parameters of selected compounds and the amounts of antioxidants in the WEC and EEC in mg/kg (WEC: Lyophilized water extract of cinnamon (Cinnamomum verum), EEC: Evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Download CSV Display Table

Figure 1. LC-MS/MS chromatograms of WEC (A) and EEC (A) from cinnamon (Cinnamomum verum). [WEC: Lyophilized water extract of cinnamon (Cinnamomum verum), EEC: Evaporated methanolic extract of cinnamon (Cinnamomum verum)]

Table 2. The reducing abilities of the WEC, EEC and standards including trolox and α-tocopherol at the same concentration (30 μg/mL) by Fe³⁺-Fe²⁺ and Fe³⁺-TPTZ transformation methods, as well as the Cu²⁺ reducing ability by the CUPRAC method (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Download CSV Display Table

Figure 2. Antioxidant activity of WEC and EEC from cinnamon (Cinnamomum verum). a. Fe³⁺ reducing assay; b. Cu²⁺ reducing ability by the CUPRAC assay; c. DPPH· scavenging assay; d. ABTS^•+ scavenging assay. [WEC: Lyophilized water extract of cinnamon (Cinnamomum verum), EEC: Evaporated ethanolic extract of cinnamon (Cinnamomum verum)]

Figure 2. Antioxidant activity of WEC and EEC from cinnamon (Cinnamomum verum). a. Fe3+ reducing assay; b. Cu2+ reducing ability by the CUPRAC assay; c. DPPH· scavenging assay; d. ABTS•+ scavenging assay. [WEC: Lyophilized water extract of cinnamon (Cinnamomum verum), EEC: Evaporated ethanolic extract of cinnamon (Cinnamomum verum)]

Figure 3. a.The main components in the WEC and EEC from cinnamon (Cinnamomum verum). b. IC values of WEC and EEC from cinnamon (Cinnamomum verum). [WEC: Lyophilized water extract of cinnamon (Cinnamomum verum), EEC: Evaporated ethanolic extract of cinnamon (Cinnamomum verum)]

Table 3. Determination of the half maximal concentrations (IC₅₀, μg/mL) of WEC and EEC standards for the DPPH^• and ABTS^•+ scavenging activities (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Download CSV Display Table

Table 4. The enzyme inhibition results (IC₅₀ values; µg/mL) of the WEC and EEC on acetylcholinesterase, α-amylase, α-glycosidase, and butyrylcholinesterase enzymes (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Download CSV Display Table

Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS

Table 3. Determination of the half maximal concentrations (IC₅₀, μg/mL) of WEC and EEC standards for the DPPH^• and ABTS^•+ scavenging activities (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Table 4. The enzyme inhibition results (IC₅₀ values; µg/mL) of the WEC and EEC on acetylcholinesterase, α-amylase, α-glycosidase, and butyrylcholinesterase enzymes (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS

Figures & data

Table 3. Determination of the half maximal concentrations (IC50, μg/mL) of WEC and EEC standards for the DPPH• and ABTS•+ scavenging activities (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Table 4. The enzyme inhibition results (IC50 values; µg/mL) of the WEC and EEC on acetylcholinesterase, α-amylase, α-glycosidase, and butyrylcholinesterase enzymes (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Table 3. Determination of the half maximal concentrations (IC₅₀, μg/mL) of WEC and EEC standards for the DPPH^• and ABTS^•+ scavenging activities (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)

Table 4. The enzyme inhibition results (IC₅₀ values; µg/mL) of the WEC and EEC on acetylcholinesterase, α-amylase, α-glycosidase, and butyrylcholinesterase enzymes (WEC: lyophilized water extract of cinnamon (Cinnamomum verum), EEC: evaporated ethanolic extract of cinnamon (Cinnamomum verum)