Oral nutrition supplement improves nutrition and inflammation of cancer patients by regulating iron metabolism

Figures & data

Table 1. Baseline data of patients with lung cancer.

	The Control group (n=45)	The ONS group (n=45)	P
Age	59±6	61±6	0.198
Gender (male)	26 (58%)	24 (53%)	0.254
BMI (kg/m^2)	18±3	19±3	0.315
Hb (g/L)	102±6	103±5	0.262
SI (μmol/L)	9±3	10±3	0.634
SF (ng/ml)	396±24	410±24	0.458
TIBC (μmol/L)	49±7	49±6	0.275
TP (g/L)	59±5	57±5	0.467
ALB(g/L)	34±5	33±5	0.512
PA(mg/L)	125±15	119±15	0.384
TNF-α (pg/ml)	19±4	21±4	0.722
IL-6 (pg/ml)	23±6	25±6	0.164
CRP (mg/L)	14±1	15±2	0.216

Values are presented as mean ± SD. BMI: Body Mass Index; Hb: hemoglobin; SI: serum iron; SF: serum ferritin; TIBC: total iron-binding capacity; TP: total protein; ALB: albumin; PA: prealbumin; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6; CRP: C-reactive protein.

Table 2. Comparison of nutritional status between two groups.

	time	The ONS group (n=45)	The Control group (n=45)	P-time	P-group	P-time×group interaction
TP (g/L)	1st day	57±5	59±5	0.217	0.045	0.281
	7th day	56±5	56±5
	14th day	59±8\^a	56±4^a
ALB (g/L)	1st day	33±5	34±5	0.286	0.034	0.304
	7th day	33±5	32±4
	14th day	37±5^a	33±4^b
PA (mg/L)	1st day	119±15	125±15	0.424	0.017	0.425
	7th day	129±16	126±15
	14th day	155±23^a	117±25^b
BMI (kg/m^2)	1st day	19±3	18±3	0.289	0.163	0.386
	7th day	19±3	18±3
	14th day	19±3^a	18±4^a

Values are presented as mean ± SD. TP: total protein, ALB: albumin, PA: prealbumin, BMI: body mass index; Groups sharing the same superscript (a or b) have no significant difference from each other in the post hoc analysis (p ≥ .05)

Table 3. Comparison of inflammation between two groups.

	Time	The ONS group (n=45)	The Control group (n=45)	P-time	P-group	P-time×group interaction
TNF-α (pg/ml)	1st day	21±4	19±4	0.413	0.018	0.412
	7th day	18±4	19±4
	14th day	10±4^a	18±4^b
IL-6 (pg/ml)	1st day	25±6	23±6	0.207	0.022	0.657
	7th day	18±4	20±4
	14th day	12±4^a	21±4^b
CRP (mg/L)	1st day	15±2	14±1	0.472	0.039	0.285
	7th day	12±2	15±2
	14th day	9±1^a	14±3^b

Values are presented as mean ± SD. Hb: hemoglobin, SI: serum iron, SF: serum ferritin, TIBC: total iron-binding capacity; Groups sharing the same superscript (a or b) have no significant difference from each other in the post hoc analysis (p ≥ .05)

Table 4. Comparison of iron metabolism between two groups.

	Time	The ONS group (n=45)	The Control group (n=45)	P-time	P-group	P-time×group interaction
Hb (g/L)	1st day	103±5	102±6	0.325	0.027	0.327
	7th day	110±6	102±6
	14th day	126±6^a	99±5^b
SI (μmol/L)	1st day	10±3	9±3	0.179	0.038	0.545
	7th day	12±4	10±4
	14th day	16±5^a	10±3^b
SF (ng/ml)	1st day	410±24	396±24	0.354	0.044	0.694
	7th day	358±24	381±25
	14th day	305±23^a	378±25^b
TIBC (μmol/L)	1st day	49±6	49±7	0.471	0.013	0.513
	7th day	55±6	45±7
	14th day	68±5^a	42±7^b

Values are presented as mean ± SD. Hb: hemoglobin, SI: serum iron, SF: serum ferritin, TIBC: total iron-binding capacity; Groups sharing the same superscript (a or b) have no significant difference from each other in the post hoc analysis (p ≥ .05)