Role of bioactive components of ginger in management of osteoarthritis: a review

Figures & data

Table 1. Bioactive components of ginger and their possible therapeutic potentials.

Bioactive components	Therapeutic potential	References
Gingerol	Anti-inflammatory Anti-oxidant activity	^[Citation17]
Zingerone	Anti-oxidant Anti-bacterial activity	^[Citation18]
Ginger flavonoids	Anti-oxidant activity	^[Citation19]
Shogoal	Anti-cancer Anti-proliferation	^[Citation20]
1-Dehydro (10) gingerdione Terpenoids	Activate p53 induce apoptosis	^[Citation21]
1,7-diarylheptane	Anti-inflammatory Antioxidant Anti-tumor Anti-hepatotoxic Chemopreventive activities	^[Citation15]

Figure 1. Molecular structure of few bioactive components found in ginger.

Table 2. Summary of the effects of Ginger on Osteoarthritis.

Patients	Form of drug	Route of administration	Duration of administration	Visual analogue scale (VAS) & WOMAC score	References
Osteoarthritis	Capsule	250 mg	6 weeks	↓5.7 mm during walking ↓5.3 mm during Standing	^[Citation4]
Knee Osteoarthritis	Capsule	255 mg	6 weeks	↓6.4 mm Walking ↓8.1 mm Standing	^[Citation24]
Knee Osteoarthritis	Capsule	500 mg	2 months	↓ VAS score	^[Citation29]
Knee Osteoarthritis	Pill	50 mg diclofenac +750 mg gingerol	5 weeks	↓WOMAC Score ↓ VAS	^[Citation30]
Knee Osteoarthritis	For message use	Gingerol oil + meloxicam 15 mg	2 times for 5 weeks	↓WOMAC Score ↓ VAS	^[Citation31]
Knee Osteoarthritis	Capsule	Ginger + glucosamine	1 month	↓ VAS	^[Citation3]

Figure 2. Anti-inflammatory role of ginger in health maladies.

Figure 3. Metabolism of Arachidonic acid involve two pathways (Cyclooxygenase pathway metabolism results in the synthesis of progesteron and thromboxanes and lypooxygenase metabolism results in the synthesis of Leukotrienes).

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Data availability statement

Data will be provided on a request basis.