Liposomes: a promising delivery system for active ingredients in food and nutrition

Figures & data

Figure 1. Most prominent methods for the preparation of liposomes.

Table 1. Liposomes in functional foods.

Functional Food	Liposomes	Experiment /Subject	Outcomes	References
Milk	Lactobacillus sakei 2a encapsulated with phosphatidylcholine and DOTAP	Liposomes added in goat milk	Listeria monocytogenes growth is suppressed.	[51]
	Soy phosphatidylcholine (SPC)-based liposomes	Liposomes encapsulated with Vitamin E and C added in chocolate milk	High percentages of vitamin E and C were observed	[47]
	Nisin and garlic extract (GE) loaded liposomes	Liposomes co-encapsulated with phosphatidylcholine added in whole milk	Nisin-GE encapsulated in nano-liposomes has the potential to be used as an antibacterial product in food.	[49]
Cheese	Lemongrass oil-loaded liposomes	Liposomes added in cheese to check the anti-biotic activities	Retard Listeria monocytogenes growth in cheese	[52]
Yogurt	Liposomes encapsulated with doum extract powder (DEP)	DEP encapsulated in liposomes added in yogurt	Enhanced functional properties of yogurt along with increased anti-oxidant activity was observed	[53]
	Sour cherry phenolics (SCE) loaded liposomes	Liposomal powder and phenolics were combined with yogurt.	Increased anti-oxidant capacity	[54]
	Nano-encapsulated fish oil liposomes	Nano-encapsulated fish oil combined with yogurt	The DHA and EPA level of yogurt fortified with nano-encapsulated fish oil was greater than that of yogurt supplemented with free fish oil.	[55]
Juices	Vitamin C-loaded liposome	Liposomes implied in mandarin juice	High microbial stability and increase shelf life	[56]
Chocolate	Black mulberry (Morus nigra) extract (BME) loaded liposomes	Fortification of chocolate with encapsulated anthocyanins	In both increased temperature and pH, chitosan coated liposomal powders exhibited superior protection of anthocyanin content.	[57]
Gummy candies	Betanin-loaded liposome	Gummy candy was selected as a food model	Increase stability and bioavailability of betanin	[58]

Table 2. Adjacent effect of Liposomes and Nutraceuticals in cancer treatment.

Nutraceutical	Targeted Cancer cells	References
Berberine	Breast cancer stem cells (CSC)	[93]
Crocin	Breast cancer	[94]
Genistein	Breast carcinoma, adenocarcinoma-ovarian	[95]
Curcumin	Pancreatic carcinoma	[74,95]
Curcumin, Genistein	Prostate cancer, Adenocarcinoma prostate	[95,96]
Curcumin	Cervical cancer cell lines	[97,98]
Curcumin	Colorectal cell lines	[85]
Fisetin	Lung Cancer	[92]
b-cryptoxanthin	Human leukemia cell line	[99]

Data availability statement

Even though adequate data has been given in the form of tables and figures, however, all authors declare that if more data is required then the data will be provided on a request basis.