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Articles

Expression analysis of MINA53: correlation with aberrantly expressed mRNAs and pathological features in non-small lung cancer

, , , , , , , , & show all
Pages 1791-1798 | Received 26 Aug 2021, Accepted 10 Dec 2021, Published online: 08 Jan 2022

Figures & data

Table 1. Association between mean RQ levels of PD-L1, STAT3, PTEN, EGFR, MINA53, mTOR and clinicopathological characteristics in patients with LUAD.

Table 2. Association between mean RQ levels of PD-L1, STAT3, PTEN, EGFR, MINA53, mTOR and clinicopathological characteristics in patients with LUSC.

Figure 1. mRNA expression levels. (A) Comparison between the levels of expression in LUAD (brick) and adjacent non-tumor tissues (turquoise) by RT-qPCR; (B) Comparison between the levels of expression in LUSC (brick) and adjacent non-tumor tissues (turquoise) by RT-qPCR; (C) Comparison between the levels of expression in LUAD (brick) and LUSC (turquoise).

Note: Criteria: Mann–Whitney U test was performed to evaluate the significance of expression level differences, p ≥ 0.05 consider as non-significant, *: p ≤ 0.05, **: p ≤ 0.01, ***: p ≤ 0.001, LUAD – lung adenocarcinoma, LUSC – lung squamous cell lung cancer

Figure 1. mRNA expression levels. (A) Comparison between the levels of expression in LUAD (brick) and adjacent non-tumor tissues (turquoise) by RT-qPCR; (B) Comparison between the levels of expression in LUSC (brick) and adjacent non-tumor tissues (turquoise) by RT-qPCR; (C) Comparison between the levels of expression in LUAD (brick) and LUSC (turquoise).Note: Criteria: Mann–Whitney U test was performed to evaluate the significance of expression level differences, p ≥ 0.05 consider as non-significant, *: p ≤ 0.05, **: p ≤ 0.01, ***: p ≤ 0.001, LUAD – lung adenocarcinoma, LUSC – lung squamous cell lung cancer

Figure 2. Linear regression and correlation analysis of the expression levels of (A) MINA53 and EGFR in LUAD samples; (B) MINA53 and PD-L1; (C) MINA53 and STAT3 in patients with LUSC.

Note: Criteria: Linear fit-line, 95% CI band and R2 are shown to illustrate the linear correlation between log2RQ values of both variables. The Pearson’s coefficient (r) and the p-value (p) are displayed.

Figure 2. Linear regression and correlation analysis of the expression levels of (A) MINA53 and EGFR in LUAD samples; (B) MINA53 and PD-L1; (C) MINA53 and STAT3 in patients with LUSC.Note: Criteria: Linear fit-line, 95% CI band and R2 are shown to illustrate the linear correlation between log2RQ values of both variables. The Pearson’s coefficient (r) and the p-value (p) are displayed.

Data availability statement

The data that support the findings of this study are available from the corresponding author, (VP), upon reasonable request.