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RESEARCH ARTICLE

Comparison of histopathologic and clinical characteristics of microsatellite instability in colorectal adenocarcinomas and its impact on survival

ORCID Icon, ORCID Icon & ORCID Icon
Article: 2356864 | Received 16 Jan 2024, Accepted 13 May 2024, Published online: 20 May 2024

Figures & data

Figure 1. Immunohistochemical PMS2, MLH1, MSH2, and MSH6 study in four different colorectal carcinoma cases. (A) Strong nuclear MLH1 expression, (B) Strong nuclear MSH2 expression, (C) Strong nuclear MSH6 expression, (D) Strong nuclear PMS2 expression in pMMR cases (immunoperoxidase, 100×). Scale bar = 500 µm.

Figure 1. Immunohistochemical PMS2, MLH1, MSH2, and MSH6 study in four different colorectal carcinoma cases. (A) Strong nuclear MLH1 expression, (B) Strong nuclear MSH2 expression, (C) Strong nuclear MSH6 expression, (D) Strong nuclear PMS2 expression in pMMR cases (immunoperoxidase, 100×). Scale bar = 500 µm.

Figure 2. Immunohistochemical PMS2, MLH1, MSH2, and MSH6 study in four different colorectal carcinoma cases. (A) Diffuse loss of MLH1 expression, (B) Diffuse loss of nuclear MSH2 expression, (C) Diffuse loss of nuclear MSH6 expression, (D) Diffuse loss of nuclear PMS2 expression in dMMR cases (immunoperoxidase, 100×) Scale bar = 500 µm.

Figure 2. Immunohistochemical PMS2, MLH1, MSH2, and MSH6 study in four different colorectal carcinoma cases. (A) Diffuse loss of MLH1 expression, (B) Diffuse loss of nuclear MSH2 expression, (C) Diffuse loss of nuclear MSH6 expression, (D) Diffuse loss of nuclear PMS2 expression in dMMR cases (immunoperoxidase, 100×) Scale bar = 500 µm.

Table 1. The comparison of age, gender, histologic subtype, and MMR status of the patients.

Figure 3. Kaplan-Meier curves for CRC patients with dMMR and pMMR.

Figure 3. Kaplan-Meier curves for CRC patients with dMMR and pMMR.

Table 2. The comparison of the clinicopathological features of the patients with their MMR status of the patients.

Table 3. Comparison of histomorphologic findings of the cases with MMR status of the patients.

Data availability Statement

The data that support the findings of this study are available from the corresponding author [UA], upon reasonable request.