An overview of the role of MMP-8 and ADAM-33 in bronchial asthma

Figures & data

Figure 1. The basic structure of MMPs and ADAMs. (A) The four common domains in MMPs: pro-peptide domain, catalytic metalloproteinase domain, hinge region and hemopexin domain. (B) Unlike MMPs, ADAMs contain a disintegrin domain, cysteine-rich domain, EGF-like domain, transmembrane region and a cytoplasmic tail (transmembrane anchor) (adapted from Edwards et al. [11,12]).

Table 1. Tissue inhibitors of metalloproteinases (TIMPs): expression and interactions (adapted from Cabral-Pacheco et al. [1]).

TIMPs	Tissue/cell expression	Localization	MMPs and ADAM inhibited	Other interactions	References
TIMP-1	Transcription inducible by cytokines and hormones: lymph nodes, brain, heart, arteries, colon, kidneys, liver, lungs, bladder, breasts, skin, ovaries, uterus, prostate, and testes	Soluble within the interstitial space of the ECM, and cell surface.	MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-19, MT1-MMP, MT3-MMP, MT5-MMP, ADAM-10	pro-MMP-9, LRP1, CD 63	[29–32]
TIMP-2	Constitutive expression: lymph nodes, brain, heart, arteries, colon, kidneys, liver, breasts, ovaries, prostate, and testes	Soluble within the interstitial space of the ECM, and cell surface.	MMP-2, MMP-9, MT1- MMP, ADAM-12	pro-MMP-2, α3β1 integrin, LRP1	[31–34]
TIMP-3	In response to mitogenic stimulation and during cell cycle progression: brain, heart, colon, kidneys, lungs, liver, breast, ovaries, prostate and testes, and eyes	Extracellular matrix and cell surface via heparan sulphate proteoglycans.	MMP-2, MMP-9, ADAM-17, ADAM-10	pro-MMP-2, pro-MMP-9	[35–38]
TIMP-4	heart, brain, breasts, uterus, ovary, kidney, pancreas, colon, testes, adipose tissue and prostate	Soluble within the interstitial space of the ECM, and cell surface.	MMP-2, MMP-26, MT1-MMP, ADAM-28	pro-MMP-2, CD 63	[20,39]
LRP1- Low density lipoprotein receptor-related protein 1

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Huang W, Li WQ, Dehnade F, et al. Tissue inhibitor of metalloproteinases-4 (TIMP-4) gene expression is increased in human osteoarthritic femoral head cartilage. J Cell Biochem. 2002;85(2):295–303. doi: 10.1002/jcb.10138.

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