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Review

Small molecule modulators of IL-17A/IL-17RA: a patent review (2013-2021)

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Pages 1161-1173 | Received 20 Mar 2022, Accepted 31 Oct 2022, Published online: 09 Nov 2022

Figures & data

Figure 1. Effects of IL-17 under different disease conditions and IL-17 receptor mediated signaling.

Figure 1. Effects of IL-17 under different disease conditions and IL-17 receptor mediated signaling.

Table 1. IL17 directed mAbs on the market and small molecules in clinical trials.

Figure 2. The examples of peptide and macrocycle and cocrystal structure of macrocycle 3 by Pfizer.

Figure 2. The examples of peptide and macrocycle and cocrystal structure of macrocycle 3 by Pfizer.

Figure 3. The general structure and examples of the macrocycles patented by Ensemble Therapeutics.

Figure 3. The general structure and examples of the macrocycles patented by Ensemble Therapeutics.

Figure 4. The general structure and examples of the linear peptide by Ensemble Therapeutics.

Figure 4. The general structure and examples of the linear peptide by Ensemble Therapeutics.

Figure 5. The general structure and examples of patented by UCB Biopharma Sprl.

Figure 5. The general structure and examples of patented by UCB Biopharma Sprl.

Figure 6. The general structure and examples of patented by UCB Biopharma Sprl.

Figure 6. The general structure and examples of patented by UCB Biopharma Sprl.

Figure 7. The general structure and examples of patented by Hitgen Inc.

Figure 7. The general structure and examples of patented by Hitgen Inc.

Figure 8. The general structure and examples of patented by Hitgen Inc.

Figure 8. The general structure and examples of patented by Hitgen Inc.

Figure 9. The general structure and examples of patented by Dice Alpha, Inc.

Figure 9. The general structure and examples of patented by Dice Alpha, Inc.

Figure 10. The general structure and examples of patented by Eli Lilly And Company.

Figure 10. The general structure and examples of patented by Eli Lilly And Company.

Figure 11. The general structure and examples of patented by Leo Pharma A/S.

Figure 11. The general structure and examples of patented by Leo Pharma A/S.