7,676
Views
11
CrossRef citations to date
0
Altmetric
Review

Small molecule modulators of IL-17A/IL-17RA: a patent review (2013-2021)

&
Pages 1161-1173 | Received 20 Mar 2022, Accepted 31 Oct 2022, Published online: 09 Nov 2022

References

  • Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 2009;9(8):556–567.
  • Li X, Bechara R, Zhao J, et al. IL-17 receptor–based signaling and implications for disease. Nat Immunol. 2019;20(12):1594–1602.
  • Jin W, Dong C . IL-17 cytokines in immunity and inflammation. Emerging Microbes and Infections. 2013; 2(1): e60.
  • McGeachy MJ, Cua DJ, Gaffen SL. The IL-17 family of cytokines in health and disease. Immunity. 2019;50(4):892–902.
  • Tollenaere MAX, Hebsgaard J, Ewald DA, et al. Signalling of multiple interleukin (IL)-17 family cytokines via IL-17 receptor A drives psoriasis-related inflammatory pathways. Br J Dermatol. 2021;185(3):585–594.
  • Ostling J, Geest M, Schofield JPR, et al. IL-17–high asthma with features of a psoriasis immunophenotype. Journal of Allergy and Clinical Immunology. 2019;144(5):1198–1213.
  • Blauvelt A, Chiricozzi A. The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis. Clin Rev Allergy Immunol. 2018;55(3):379–390.
  • Kirkham BW, Kavanaugh A, Reich K. Interleukin-17A: a unique pathway in immune- mediated diseases psoriasis, psoriatic arthritis and rheumatoid arthritis. Immunology. 2014;141(2):133–142.
  • Thomas LW, Lee EB, Wu -J-J. Systematic review of anti-drug antibodies of IL-17 inhibitors for psoriasis. J Dermatolog Treat. 2019;30(2):110–116.
  • Fu J, Huang Y, Bao T, et al. The role of Th17 cells/IL‑17A in AD, PD, ALS and the strategic therapy targeting on IL17A. J Neuroinflammation. 2022;19(1):98–110.
  • Chen J, Liu X, Zhong Y. Interleukin-17A: the key cytokine in neurodegenerative diseases. Front Aging Neurosci. 2020;12:566922.
  • Wang W-J, Groves MR, Dömling A. Artificial macrocycles as IL-17A/IL-17RA Antagonists. Med Chem Commun. 2018;9(1):22–26.
  • Liu S-P, Song X, Chrunyk BA. Crystal structures of interleukin 17A and its complex with IL-17 receptor A. Nat Commun. 2013;4(1):1888–1897.
  • Espada A, Broughton H, Jones S. A binding site on IL-17A for inhibitory macrocycles revealed by hydrogen/deuterium exchange mass spectrometry. J Med Chem. 2016;59(5):2255–2260.
  • Liu S-P, Dakin LA, Xing L, et al., Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Sci Rep. 2016. 6(1): 30859.
  • Liu S-P, Desharnais J, Sahasrabudhe PV, et al. Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.Scientific Reports. 2016;6:26071.
  • Ensemble Therapeutics Corporation. Macrocyclic compounds for modulating IL-17. WO2013116682A1. 2013.
  • Ensemble Therapeutics Corporation. Macrocyclic compounds for modulating IL-17. US20150005319A1. 2015.
  • Ensemble Therapeutics Corporation. Compounds for modulating IL-17. WO2014066726A2. 2014.
  • Ucb Biopharma Sprl. Spirocyclic indolines as IL-17 modulators. WO2018229079A1. 2018.
  • Ucb Biopharma Sprl. Fused imidazole derivatives as IL-17 modulators. WO2019138017A1. 2019.
  • Ucb Biopharma Sprl. Spirocyclic indane analogues as IL-17 modulators. WO2020011731A1. 2020.
  • Ucb Biopharma Sprl. Benzimidazolone derivatives, and analogues thereof, as IL-17 modulators. WO2020120140A1. 2020.
  • Ucb Biopharma Sprl. Benzimidazolone derivatives, and analogues thereof, as IL-17 modulators. WO2020120141A1. 2020.
  • Ucb Biopharma Sprl. Fused imidazole derivatives as IL-17 modulators. WO2020260425A1. 2020.
  • Ucb Biopharma Sprl. Fused imidazole derivatives as IL-17 modulators. WO2020260426A1. 2020.
  • Ucb Biopharma Sprl. Imidazopyridine derivatives as IL-17 modulators. WO2020261141A1. 2020.
  • Ucb Biopharma Sprl. Difluorocyclohexyl derivatives as IL-17 modulators. WO2021170627A1. 2021.
  • Ucb Biopharma Sprl. Difluorocyclohexyl derivatives as IL-17 modulators. WO2021170631A1. 2021.
  • Ucb Biopharma Sprl. Difluorocyclohexyl derivatives as IL-17 modulators. WO2021204800A1. 2021.
  • Ucb Biopharma Sprl. Difluorocyclohexyl derivatives as IL-17 modulators. WO2021204801A1. 2021.
  • Hitgen Inc. Preparation of immunomodulator for treating IL-17A mediated diseases. WO2019223718A1. 2019.
  • Hitgen Inc. Enantioselective prepn. of ((methyl)pyrazolecarboxamido)methyl benzimidazoles as IL-17 immunomodulators. CN112341435A. 2021.
  • Hitgen Inc. Preparation of (benzimidazolyl)(cyclobutylmethyl)acetamides as IL-17 immunomodulators. CN112341439A. 2021.
  • Hitgen Inc. Preparation of imidazole derivatives as immunomodulators and used for treating IL-17A-mediated diseases. CN112341440A. 2021.
  • Hitgen Inc. Enantioselective preparation of ((methyl)pyrazolecarboxamido)methyl benzimidazoles as IL-17 immunomodulators. CN112341441A.
  • Hitgen Inc. Enantioselective preparation of (benzimidazolyl)oxypyrrolidine carboxylates as IL-17 immunomodulators. CN112341442A. 2021.
  • Hitgen Inc. Preparation of benzimidazole derivatives as immune regulators. CN112341446A. 2021.
  • Hitgen Inc. Preparation of benzimidazole derivatives as immune regulators. CN112341450A. 2021.
  • Hitgen Inc. Compound as IL-17A inhibitor and use in the preparation of drugs for treating IL-17A-mediated diseases thereof. CN112341451A. 2021.
  • Hitgen Inc. Immunomodulator, and application thereof in treating IL-17A mediated disease. CN112341519A. 2021.
  • Dice Alpha Inc. IL-17 Ligands And Uses Thereof. US2020247785A1. 2020.
  • Dice Alpha Inc. IL-17A modulators and uses thereof. WO2021055376A1. 2021.
  • Eli Lilly And Company. Imidazo[1,2-b]pyridazine IL-17A inhibitors. WO2020146194A1. 2020.
  • Leo Pharma A/S. Amino-acid anilides as small molecule modulators of IL-17. WO2020127685A1. 2020.
  • Leo Pharma A/S. Amino-acid anilides as small molecule modulators of IL-17. WO2020182666A1. 2020.
  • Leo Pharma A/S. Small molecule modulators of IL-17. WO2021250194A1. 2021.
  • Leo Pharma A/S. Small molecule modulators of IL-17. WO2021255086A1. 2021.
  • Leo Pharma A/S. Small molecule modulators of IL-17. WO2021255174A1. 2021.