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Abstract
Background There are virtually no prospective cohort studies in Germany regarding the changes of menopausal hormone therapy (HT) use pattern and factors associated with HT discontinuation after the release of the Women's Health Initiative (WHI) trial results.
Methods We assessed HT prevalence and use pattern as well as factors associated with HT discontinuation in a cohort of 903 women 40 years of age and older, who participated in two consecutive follow-up visits in a 20-year prospective health study from July 2000 to February and from August 2002 to December 2004.
Results Overall, the prevalence of HT users in the cohort declined significantly from 35.4% in 2000–2002 to 22.5% in 2002–2004. Adjusting for aging of the population, a statistically significant decrease in HT user prevalence was consistently observed across subgroups of HT users defined by type and duration of HT use. The decline was most pronounced with respect to women using combined estrogen–progestin regimens (−10.5%), higher-dose estrogens (−11.6%), oral preparations (−11.1%), as well as long-term HT users (−8.4%). The prevalence of women indicating HT use for climacteric symptoms decreased significantly (−12.4%), whereas the prevalence of women reporting use of HT for the prevention of osteoporosis increased (+1.8%) significantly. Irrespective of hysterectomy status, half of the women who continued HT changed their HT preparations and switched to lower estrogen doses (11.5%), topical estrogens (8.2%), or phytohormones (3.8%). We did not observe any significant differences between women who continued and discontinued HT regarding health-related characteristics of the study population as of 2000–2002. However, women seeing a gynecologist in the 12 months preceding the 2002–2004 visit were significantly less likely to discontinue HT use in bivariate and multivariate analyses.
Conclusions Substantial declines in HT user prevalence as well as changes in HT use patterns to lower-dose estrogen preparations and non-oral routes of administration are likely to reflect effects of the publication of the WHI results. Consulting a gynecologist appeared to be relevant for a woman's decision to continue HT.