Figures & data
Table 1. Overview of main publications with 0.03 mg estriol (E3)–Lactobacillus acidophilus KS400 combination (0.03 mg-E3/L) relating to the treatment of vaginal atrophy.
Lamont R, Sobel J, Akins R, et al. The vaginal microbiome: new information about genital tract flora using molecular based techniques. Bjog 2011;118:533–49 Witkin SS, Linhares IM, Giraldo P, et al. An altered immunity hypothesis for the development of symptomatic bacterial vaginosis. Clin Infect Dis 2007;44:554–7 Unlu C, Donders G. Use of lactobacilli and estriol combination in the treatment of disturbed vaginal ecosystem: a review. J Turk Ger Gynecol Assoc 2011;12:239–46 Heimer GM, Englund DE. Plasma oestriol following vaginal administration: morning versus evening insertion and influence of food. Maturitas 1986;8:239–43 van der Vies J. The pharmacology of oestriol. Maturitas 1982;4:291–9 Kaiser RR, Michael-Hepp J, Weber W, et al. Absorption of estriol from vaginal tablets after single and repeated application in healthy, postmenopausal women. Therapiewoche 2000;3:2–8 Kanne B, Jenny J. [Local administration of low-dosed estriol and viable Lactobacillus acidophilus in the post-menopausal period]. Gynäkol Rundsch 1991;31:7–13 [German] Feiks A, Grunberger W. [Treatment of atrophic vaginitis: does topical application allow a reduction in the oestrogen dose?]. Gynäkol Rundsch 1991;31(Suppl 2):268–71 [German] Jaisamrarn U, Triratanachat S, Chaikittisilpa S, et al. Ultra-low-dose estriol and lactobacilli in the local treatment of postmenopausal vaginal atrophy: a double-blind randomized trial followed by open-label maintenance therapy. Climacteric 2013;16:347–55 Donders G, Neven P, Moegele M, et al. Ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets (Gynoflor(®)) for vaginal atrophy in postmenopausal breast cancer patients on aromatase inhibitors: pharmacokinetic, safety, and efficacy phase I clinical study. Breast Cancer Res Treat 2014;145:371–9 Buchholz S, Mogele M, Lintermans A, et al. Vaginal estriol-lactobacilli combination and quality of life in endocrine-treated breast cancer. Climacteric 2015;18:252–9 Donders G, Bellen G, Neven P, et al. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor(R)) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis 2015;34:2023–8 Capobianco G, Wenger JM, Meloni GB, et al. Triple therapy with Lactobacilli acidophili, estriol plus pelvic floor rehabilitation for symptoms of urogenital aging in postmenopausal women. Arch Gynecol Obstet 2014;289:601–8