Figures & data
Figure 1. (a) Vasorelaxant effect of DEAm on the contraction induced by NA (0.1 μM) in endothelium-intact and -denuded aortic rings, (b) vasorelaxant effect of DEAm on the contraction induced by KCl (80 mM) on endothelium-denuded aortic rings. Results are presented as mean ± SEM, n = 6, *p < 0.05 compared with control.
Figure 2. (a) Inhibitory effects of DEAm on the cumulative contraction induced by NA (0.1 nM to 10 μM) in endothelium-denuded aortic rings, (b) inhibitory effect of DEAm on the cumulative-contraction effect dependent on extracellular Ca2+ influx induced by KCl (80 mM) in Ca2+-free solution, and (c) effect of TEA (5 mM) on DEAm induced relaxation in endothelium-denuded aortic rings pre-contracted by NA (0.1 μM). Results are presented as mean ± SEM, n = 6, *p < 0.05 compared with control.
Table 1. Relaxatory effects induced by test samples on the contraction induced by NA (0.1 μM).
Figure 3. Bio-guided fractionation of A. mexicana by using column chromatography and the chemical structure of acacetin, UA, and OA.
Figure 4. Percentage inhibition of primary fractions obtained DEAm phytochemical study. Results are presented as mean ± SEM, n = 6, *p < 0.05 compared with control.
Figure 5. AUC of the selective signals and their corresponding integrals of the mixture of acacetin/UA/OA.
Figure 6. (a) Vasorelaxant effect of acacetin on the contraction induced by NA (0.1 μM) in endothelium-denuded aortic rings and (b) vasorelaxant effect of UA on the contraction induced by NA (0.1 μM) in endothelium-denuded aortic rings. Results are presented as mean ± SEM, n = 6, *p < 0.05 compared with control.
Figure 7. Maximal decreases in (a) SBP, (b) DBP and (c) HR (mmHg) elicited by oral administration of 50 mg/kg of UA in conscious rats. Results are expressed as SEM, n = 6 rats per group, *p < 0.05 with respect to conscious vehicle pre-treated rats.
