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Pharmaceutical Biology Volume 55, 2017 - Issue 1
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Research Article

Bioassay-guided fractionation and identification of α-amylase inhibitors from Syzygium cumini leaves

Jeyakumaran Poongunrana Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka;
,
Handunge Kumudu Irani Pererab Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka; Correspondence[email protected]
,
Lalith Jayasinghec Institute of Fundamental Studies, Kandy, Sri Lanka;
,
Irushika Thushari Fernandob Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka;
,
Ramaiah Sivakanesanb Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka;
,
Hiroshi Arayad School of Agriculture, Meiji University, Tama-ku, Kanagawa, Japan
&
Yoshinori Fujimotoc Institute of Fundamental Studies, Kandy, Sri Lanka; ;d School of Agriculture, Meiji University, Tama-ku, Kanagawa, Japan
 show all
Pages 206-211 | Received 23 May 2016, Accepted 29 Oct 2016, Published online: 07 Dec 2016

Figures & data

Figure 1. TLC of the active fractions before and after final purification. (A) Prior to the final purification, (B) After the final purification with PTLC Solvent mixture: 5% MeOH: Chloroform.

Figure 1. TLC of the active fractions before and after final purification. (A) Prior to the final purification, (B) After the final purification with PTLC Solvent mixture: 5% MeOH: Chloroform.

Figure 2. Structures of Oleanolic acid (OA) and Ursolic acid (UA).

Figure 2. Structures of Oleanolic acid (OA) and Ursolic acid (UA).

Table 1. Porcine pancreatic α-amylase inhibitory activity of SC fractions.

Table 2. Percentage inhibition of α-amylase and α-glucosidase by pure fraction.

Table 3. Percentage inhibition of α-amylase and α-glucosidase by ursolic acid.

Table 4. Percentage inhibition of α-amylase and α-glucosidase by oleanolic acid.

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