Roles of TRPM channels in glioma

Figures & data

Figure 1. Members and general structure of the TRPM channels.

Figure 2. Activation mechanisms of the TRPM channels.

Figure 3. The main TRPMs-mediated mechanisms and signaling pathways associated with the development and progression of glioma.

Figure 4. Structure of chemical agonists and antagonists of the TRPM channels in glioma.

Table 1. Chemical inhibitors and activators of the TRPM family in glioma.

TRPM channels	Compound	Inhibitors and activators	IC50 (μM)	Defining structure	Chemical structure	Assay type	Reference
TRPM2	curcumin	inhibitor	4.8	Nudix box motif	Figure 3(a)	Electrophysiology	^Citation157,Citation158
	BTX-A	activator	n.d		Figure 3(a)	Calcium flux	^Citation158
	DTX	activator	n.d		Figure 3(a)	Electrophysiology	^Citation159
	PTX	activator	0.176		Figure 3(a)	Electrophysiology	^Citation160
	resveratrol	activator	6.7		Figure 3(a)	Electrophysiology	^Citation160,Citation161
TRPM3	n.d.	n.d	n.d	n.d	n.d	n.d	n.d
TRPM7	carvacrol	inhibitor	306	Serine/ threonine kinase domain	Figure 3(b)	Electrophysiology	^Citation112
	NS8593	inhibitor	1.6		Figure 3(b)	Electrophysiology	^Citation166
	VQ-1	inhibitor	n.d		Figure 3(b)	Electrophysiology	^Citation165
TRPM8	menthol	activator	11.8	n.d	Figure 3(c)	Electrophysiology	^Citation55,Citation167
	icilin	activator	0.058		Figure 3(c)	Electrophysiology	^Citation57,Citation94

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