Figures & data
Figure 1. Participation of Gli1+ and Lepr+ cells in bone marrow fibrosis in myelofibrosis. It is well accepted that the bone marrow hosts various cells with distinct functions in its microenvironment. Gli1+ cells are present around the endosteum and the blood vessels, while LepR+ cells are located mainly around sinusoids. The studies of Decker et al. (2017) and Schneider et al. (2017) now reveal that Gli1+ and LepR+ cells are recruited from endosteal and perivascular regions giving rise to fibrotic cells that contribute to the development of fibrosis in the bone marrow.Citation21,22
