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LepR+ cells dispute hegemony with Gli1+ cells in bone marrow fibrosis

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Pages 2018-2022 | Received 16 Jun 2017, Accepted 07 Aug 2017, Published online: 04 Oct 2017

References

  • Dameshek W. Some speculations on the myeloproliferative syndromes. Blood. 1951;6:372-5. PMID:14820991
  • Fleischman AG, Maziarz RT. Hematopoietic stem cell transplantation for myelofibrosis: where are we now? Curr Opin Hematol. 2013;20:130-6. doi:10.1097/MOH.0b013e32835dd862. PMID:23314844
  • Tefferi A. How I treat myelofibrosis. Blood. 2011;117:3494-504. doi:10.1182/blood-2010-11-315614. PMID:21200024
  • Abdel-Wahab OI, Levine RL. Primary myelofibrosis: update on definition, pathogenesis, and treatment. Annual Rev Med. 2009;60:233-45. doi:10.1146/annurev.med.60.041707.160528
  • Dias Moura Prazeres PH, Sena IFG, Borges IDT, de Azevedo PO, Andreotti JP, de Paiva AE, de Almeida VM, de Paula Guerra DA, Pinheiro Dos Santos GS, Mintz A, et al. Pericytes are heterogeneous in their origin within the same tissue. Dev Biol. 2017;427:6-11. doi:10.1016/j.ydbio.2017.05.001. PMID:28479340
  • Coatti GC, Frangini M, Valadares MC, Gomes JP, Lima NO, Cavacana N, Assoni AF, Pelatti MV, Birbrair A, de Lima ACP, Singer JM, Rocha FMM, Da Silva GL, Mantovani MS, Macedo-Souza LI, Ferrari MFR, Zatz M. Pericytes extend survival of ALS SOD1 mice and induce the expression of antioxidant enzymes in the murine model and in IPSCs derived neuronal cells from an ALS patient. Stem Cell Rev 2017. doi:10.1007/s12015-017-9752-2. PMID:28710685
  • Birbrair A, Delbono O. Pericytes are Essential for Skeletal Muscle Formation. Stem Cell Rev. 2015;11:547-8. doi:10.1007/s12015-015-9588-6. PMID:25896402
  • Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, et al. Novel peripherally derived neural-like stem cells as therapeutic carriers for treating glioblastomas. Stem Cells Translational Med. 2017;6:471-81. doi:10.5966/sctm.2016-0007
  • Birbrair A, Wang ZM, Messi ML, Enikolopov GN, Delbono O. Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle. PloS One. 2011;6:e16816. doi:10.1371/journal.pone.0016816. PMID:21304812
  • Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Therapy. 2014;5:122. doi:10.1186/scrt512
  • Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle neural progenitor cells exhibit properties of NG2-glia. Exp Cell Res. 2013;319:45-63. doi:10.1016/j.yexcr.2012.09.008. PMID:22999866
  • Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle pericyte subtypes differ in their differentiation potential. Stem Cell Res. 2013;10:67-84. doi:10.1016/j.scr.2012.09.003. PMID:23128780
  • Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Role of pericytes in skeletal muscle regeneration and fat accumulation. Stem Cells Dev. 2013;22:2298-314. doi:10.1089/scd.2012.0647. PMID:23517218
  • Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle. Frontiers Aging Neurosci. 2014;6:245. doi:10.3389/fnagi.2014.00245
  • Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes at the intersection between tissue regeneration and pathology. Clin Sci (Lond). 2015;128:81-93. doi:10.1042/CS20140278. PMID:25236972
  • Birbrair A, Zhang T, Wang Z-M, Messi ML, Olson JD, Mintz A, Delbono O. Type-2 pericytes participate in normal and tumoral angiogenesis. Am J Physiol-Cell Physiol. 2014;307:C25-C38. doi:10.1152/ajpcell.00084.2014. PMID:24788248
  • Birbrair A, Borges IDT, Gilson Sena IF, Almeida GG, da Silva Meirelles L, Goncalves R, Mintz A, Delbono O. How plastic are pericytes? Stem Cells Dev. 2017;26(14):1013-1019. doi:10.1089/scd.2017.0044. PMID:28490256
  • Prazeres PHDM, Almeida VM, Lousado L, Andreotti JP, Paiva AE, Santos GSP, Azevedo PO, Souto L, Almeida GG, Filev R, et al. Macrophages generate pericytes in the developing brain. Cell Mol Neurobiol. 2017. In press.
  • Almeida VM, Paiva AE, Sena IFG, Mintz A, Magno LAV, Birbrair A. Pericytes make spinal cord breathless after injury. Neuroscientist. 2017. In press. doi: 10.1177/1073858417731522
  • Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle. Am J Physiol Cell Physiol. 2013;305:C1098-113. doi:10.1152/ajpcell.00171.2013. PMID:24067916
  • Decker M, Martinez-Morentin L, Wang G, Lee Y, Liu Q, Leslie J, Ding L. Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis. Nat Cell Biol. 2017;19:677-88. doi:10.1038/ncb3530. PMID:28481328
  • Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Busche G, Fleck D, et al. Gli1+ mesenchymal stromal cells are a key driver of bone marrow fibrosis and an important cellular therapeutic target. Cell Stem Cell. 2017;20(6):785-800.e8. doi:10.1016/j.stem.2017.03.008. PMID:28457748
  • Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013;502:637-43. doi:10.1038/nature12612. PMID:24107994
  • Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A, Ma'ayan A, Frenette PS. Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nat Cell Biol. 2017;19:214-23. doi:10.1038/ncb3475. PMID:28218906
  • Birbrair A, Frenette PS. Niche heterogeneity in the bone marrow. Annals N York Acad Sci. 2016;1370:82-96. doi:10.1111/nyas.13016
  • Kopp HG, Avecilla ST, Hooper AT, Rafii S. The bone marrow vascular niche: home of HSC differentiation and mobilization. Physiol. 2005;20:349-56. doi:10.1152/physiol.00025.2005
  • Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. 2014;15:154-68. doi:10.1016/j.stem.2014.06.008. PMID:24953181
  • Sena I, Prazeres P, Santos G, Borges I, Azevedo P, Andreotti J, Almeida V, Paiva A, Guerra D, Lousado L, Souto L, Mintz A, Birbrair A. Identity of gli1+ cells in the bone marrow. Exp Hematol. 2017 Jul 6. pii: S0301-472X(17)30612-4. doi:10.1016/j.exphem.2017.06.349. In press.
  • DeFalco J, Tomishima M, Liu H, Zhao C, Cai X, Marth JD, Enquist L, Friedman JM. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science. 2001;291:2608-13. doi:10.1126/science.1056602. PMID:11283374
  • Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC. Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood. 2008;111:3931-40. doi:10.1182/blood-2007-08-107748. PMID:18160670
  • Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214:199-210. doi:10.1002/path.2277. PMID:18161745
  • Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002;3:349-63. doi:10.1038/nrm809. PMID:11988769
  • Hinz B. The myofibroblast: paradigm for a mechanically active cell. J Biomechanics. 2010;43:146-55. doi:10.1016/j.jbiomech.2009.09.020
  • Kuter DJ, Bain B, Mufti G, Bagg A, Hasserjian RP. Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres. British J Haematol. 2007; 139:351-62. doi:10.1111/j.1365-2141.2007.06807.x. PMID:17910625
  • Zhang K, Rekhter MD, Gordon D, Phan SH. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study. Am J Pathol. 1994;145:114-25. PMID:7518191
  • Hinz B. Formation and function of the myofibroblast during tissue repair. J Invest Dermatol. 2007;127:526-37. doi:10.1038/sj.jid.5700613. PMID:17299435
  • Berndt A, Kosmehl H, Katenkamp D, Tauchmann V. Appearance of the myofibroblastic phenotype in Dupuytren's disease is associated with a fibronectin, laminin, collagen type IV and tenascin extracellular matrix. Pathobiol J Immunopathol Mol Cell Biol. 1994;62:55-8. doi:10.1159/000163879
  • Magro G, Fraggetta F, Colombatti A, Lanzafame S. Myofibroblasts and extracellular matrix glycoproteins in palmar fibromatosis. General Diagnostic Pathol. 1997;142:185-90
  • Mahida YR, Beltinger J, Makh S, Goke M, Gray T, Podolsky DK, Hawkey CJ. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. Am J Physiol. 1997;273:G1341-8. PMID:9435560
  • Paiva AE, Lousado L, Almeida VM, Andreotti J, Santos GSP, Azevedo PO, Sena IFG, Prazeres PHDM, Borges IT, Azevedo V, et al. Endothelial cells as precursors for osteoblasts in the metastatic prostate cancer bone. Neoplasia. 2017. In press.
  • Borges IDT, Sena IFG, de Azevedo PO, Andreotti JP, de Almeida VM, de Paiva AE, Pinheiro Dos Santos GS, de Paula Guerra DA, Dias Moura Prazeres PH, Mesquita LL, Silva LSB, Leonel C, Mintz A, Birbrair A. Lung as a niche for hematopoietic progenitors. Stem Cell Rev Reports. 2017 Jul 1. doi:10.1007/s12015-017-9747-z. In press. PMID:28669077
  • Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal-Estape A, Pinho S, Ciero P, Nakahara F, Ma'ayan A, et al. Fetal liver hematopoietic stem cell niches associate with portal vessels. Science. 2016;351:176-80. doi:10.1126/science.aad0084. PMID:26634440
  • Andreotti JP, Mesquita L, Magno LAV, Birbrair A. Hypothalamic neurons take center stage in the neural stem cell niche. Cell Stem Cell. 2017. In press. doi:10.1016/j.stem.2017.08.005
  • Azevedo PO, Lousado L, Paiva AE, Andreotti JP, Santos GSP, Sena IFG, Prazeres PHDM, Filev R, Mintz A, Birbrair A. Endothelial cells maintain neural stem cells quiescent in their niche. Neuroscience. 2017. In press.
  • Lousado L, Andreotti JP, Paiva AE, Azevedo PO, Prazeres PHDM, Santos GSP, Filev R, Mintz A, Birbrair A. Schwann cell precursors as a source for adrenal gland chromaffin cells. Cell Death and Dis. 2017. In press.
  • Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481:457-62. doi:10.1038/nature10783. PMID:22281595
  • Srinivas U, Pillai LS, Kumar R, Pati HP, Saxena R. Bone marrow aplasia–a rare complication of imatinib therapy in CML patients. Am J Hematol. 2007;82:314-6. doi:10.1002/ajh.20776. PMID:17013815
  • Lauth M, Bergstrom A, Shimokawa T, Toftgard R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007;104:8455-60. doi:10.1073/pnas.0609699104. PMID:17494766
  • Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 2006;66:6063-71. doi:10.1158/0008-5472.CAN-06-0054. PMID:16778178
  • Sterling JA, Oyajobi BO, Grubbs B, Padalecki SS, Munoz SA, Gupta A, Story B, Zhao M, Mundy GR. The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells. Cancer Res. 2006;66:7548-53. doi:10.1158/0008-5472.CAN-06-0452. PMID:16885353

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