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Articles

Dysfunctional Bronchial Cilia Are a Feature of Chronic Obstructive Pulmonary Disease (COPD)

, ORCID Icon, , ORCID Icon, , , ORCID Icon, , , , , ORCID Icon, , & ORCID Icon show all
Pages 657-663 | Received 07 Apr 2021, Accepted 30 Jul 2021, Published online: 01 Sep 2021

Figures & data

Table 1. Patient characteristics.

Figure 1. Legend: Bronchial ciliary function in COPD and controls. (A) CBF: ciliary beat frequency, (B) dyskinesia index, (C) immotility index. ***p < 0.001.

Figure 1. Legend: Bronchial ciliary function in COPD and controls. (A) CBF: ciliary beat frequency, (B) dyskinesia index, (C) immotility index. ***p < 0.001.

Table 2. Ciliary function in COPD and controls.

Figure 2. Legend: transmission electron microscopy (TEM) images of ciliated respiratory epithelium from a healthy ex-smoking control subject (A) showing normal mitochondria (arrow), and a patient with COPD (B–F) showing significant loss of cilia (B), abnormal mitochondria (C), projecting cell (D), cytoplasmic bleb (E) and dead cell (F). Internal scale bar = 2 µm.

Figure 2. Legend: transmission electron microscopy (TEM) images of ciliated respiratory epithelium from a healthy ex-smoking control subject (A) showing normal mitochondria (arrow), and a patient with COPD (B–F) showing significant loss of cilia (B), abnormal mitochondria (C), projecting cell (D), cytoplasmic bleb (E) and dead cell (F). Internal scale bar = 2 µm.

Table 3. Ultrastructure of bronchial epithelium in COPD and controls.

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