Figures & data
Figure 1. During generation of iPSCs derived cholangiocytes, the key transcription factors that guide the specification of definitive endoderm cells (DE) and hepatoblasts stages are pointed out in the figure, which should be well evaluated. Those factors that favor commitment of hepatoblasts to the hepatocytic lineage should be down regulated during the cholangiocyte differentiation. Several markers are showed in the figure that can be used to recognize mature cholangiocytes, and thus evaluate the differentiation process; these also include cell ultrastructural components and transporters that are essential for normal cholangitic function.
