Figures & data
Figure 1. The primary role of the human peroxisomal AAA-complex is to prevent pexophagy. Both yeast (Pex1, Pex6 and Pex15) and human (PEX1, PEX6 and PEX26) AAA-complexes extract Ub-PEX5 from the peroxisomal membrane. However, while the main purpose of such extraction in yeast cells is Pex5 recycling for repeated rounds of PTS1-protein import, the extraction of Ub-PEX5 in human cells is essential to prevent pexophagy. Since the yeast AAA-complex also prevents pexophagy, but independent of Pex5, there must be another pexophagic signal (protein X) removed from the peroxisomal membrane by the AAA-complex in yeast.
