http://orcid.org/0000-0002-0536-8678View further author information & http://orcid.org/0000-0001-7807-2563View further author informationFigure 1. Schematic representation of karyoptosis. Upon blockage of autophagy and Golgi-mediated degradation, LMNB1, LC3 and SQSTM1 are excreted in microvesicles, the cell atrophies, cytoplasm shrinks and the nucleus degenerates, losing a regular shape and accumulating DNA damage.
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