http://orcid.org/0000-0002-9334-4405
Figures & data
Figure 1. Comparison of aspirin with other caloric-restriction mimetics. (A). Caloric-restriction mimetics may directly inhibit acetyltransferases, deplete acetyl coenzyme A (AcCoA) or activate deacetylases to stimulate protein deacetylation and consequent autophagy induction. (B) Salicylate generated from its prodrug, aspirin, directly inhibits the acetyltransferase activity of EP300, thus acting as a class I caloric-restriction mimetic to induce protein deacetylation and autophagy.
