Advanced search
Publication Cover
Autophagy Volume 14, 2018 - Issue 7
Submit an article Journal homepage
2,423
Views
15
CrossRef citations to date
0
Altmetric
Commentary

Phasing out the bad—How SQSTM1/p62 sequesters ubiquitinated proteins for degradation by autophagy

Gabriele ZaffagniniDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaORCID Iconhttp://orcid.org/0000-0002-6554-7352View further author information
ORCID Icon,
Adriana SavovaDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaView further author information
,
Alberto DanieliDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaView further author information
,
Julia RomanovDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaView further author information
,
Shirley TremelStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, GermanyView further author information
,
Michael EbnerDepartment of Structural and Computational Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaORCID Iconhttp://orcid.org/0000-0003-4234-7187View further author information
ORCID Icon,
Thomas PeterbauerDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaORCID Iconhttp://orcid.org/0000-0002-2362-5711View further author information
ORCID Icon,
Martin SztachoDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaView further author information
,
Riccardo TrapannoneDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaView further author information
,
Abul K. TarafderStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, GermanyView further author information
,
Carsten SachseStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, GermanyORCID Iconhttp://orcid.org/0000-0002-1168-5143View further author information
ORCID Icon &
Sascha MartensDepartment of Biochemistry and Cell Biology, Max F. Perutz Laboratories (MFPL), Vienna Biocenter (VBC), University of Vienna, Vienna, AustriaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3786-8199View further author information
ORCID Icon show all
Pages 1280-1282 | Received 27 Mar 2018, Accepted 03 Apr 2018, Published online: 20 Jul 2018

Figures & data

Figure 1. Model for the crosslinking of SQSTM1/p62 filaments by ubiquitinated proteins, and the coordination of this process with the activity of the UPS and the autophagy machinery. The figure was taken from Zaffagnini et al., EMBO J, 2018, doi: 10.15252/embj.201798308 with permission of the publisher.

Figure 1. Model for the crosslinking of SQSTM1/p62 filaments by ubiquitinated proteins, and the coordination of this process with the activity of the UPS and the autophagy machinery. The figure was taken from Zaffagnini et al., EMBO J, 2018, doi: 10.15252/embj.201798308 with permission of the publisher.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.