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Commentary

Autophagy promotes visceral aging in wild-type C. elegans

ORCID Icon &
Pages 731-732 | Received 20 Sep 2018, Accepted 11 Dec 2018, Published online: 30 Jan 2019

Figures & data

Figure 1. Autophagy promotes aging in a gender-specific manner in C. elegans. High autophagy in the gut (blue) allows adult C. elegans hermaphrodites (left) to produce more yolk and maximize reproductive output. However, it leads to senescent gut atrophy (red) and yolk steatosis (orange). This is driven by an IIS-activated reproductive program that is repressed in males (right) by mab-3 activity.

Figure 1. Autophagy promotes aging in a gender-specific manner in C. elegans. High autophagy in the gut (blue) allows adult C. elegans hermaphrodites (left) to produce more yolk and maximize reproductive output. However, it leads to senescent gut atrophy (red) and yolk steatosis (orange). This is driven by an IIS-activated reproductive program that is repressed in males (right) by mab-3 activity.