Autophagy, Volume 15, Issue 4 (2019)

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Autophagy, Volume 15, Issue 4 (2019)

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Editor’s Corner

Editorial
Spatially distinct pools of TORC1 balance protein homeostasis
Vikramjit Lahiri & Daniel J. Klionsky
Pages: 561-564
Published online: 06 Feb 2019
AbstractforSpatially distinct pools of TORC1 balance protein homeostasis | Full Text | References | PDF (521.1 KB) | EPUB
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Research Paper - Basic Science

Article
AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells
Huifeng Pi, Min Li, Lingyun Zou, Min Yang, Ping Deng, Tengfei Fan, Menyu Liu, Li Tian, Manyu Tu, Jia Xie, Mengyan Chen, Huijuan Li, Yu Xi, Lei Zhang, Mindi He, Yonghui Lu, Chunhai Chen, Tao Zhang, Zheng Wang, Zhengping Yu, Feng Gao & Zhou Zhou
Pages: 565-582
Published online: 20 Oct 2018
AbstractforAKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Research Paper

Article
The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau)
Yin Xu, Sheng Zhang & Hui Zheng
Pages: 583-598
Published online: 16 Oct 2018
AbstractforThe cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau) | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Article
The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis
Shashank Rai, Maryam Arasteh, Matthew Jefferson, Timothy Pearson, Yingxue Wang, Weijiao Zhang, Bertalan Bicsak, Devina Divekar, Penny P. Powell, Ronald Naumann, Naiara Beraza, Simon R. Carding, Oliver Florey, Ulrike Mayer & Thomas Wileman
Pages: 599-612
Published online: 07 Nov 2018
AbstractforThe ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Research Paper - Basic Science

Article
USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy
Marzia Raimondi, Daniela Cesselli, Carla Di Loreto, Francesco La Marra, Claudio Schneider & Francesca Demarchi
Pages: 613-630
Published online: 29 Oct 2018
AbstractforUSP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
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Article
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
Paola Rusmini, Katia Cortese, Valeria Crippa, Riccardo Cristofani, Maria Elena Cicardi, Veronica Ferrari, Giulia Vezzoli, Barbara Tedesco, Marco Meroni, Elio Messi, Margherita Piccolella, Mariarita Galbiati, Massimiliano Garrè, Elena Morelli, Thomas Vaccari & Angelo Poletti
Pages: 631-651
Published online: 05 Nov 2018
AbstractforTrehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration | Full Text | References | PDF (6 MB) | EPUB | Supplemental
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Research Paper

Article
EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation
M.S. Gilardini Montani, R. Santarelli, M. Granato, R. Gonnella, M.R. Torrisi, A. Faggioni & M. Cirone
Pages: 652-667
Published online: 23 Oct 2018
AbstractforEBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation | Full Text | References | PDF (3 MB) | EPUB
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Article
GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells
Zhen Yang, Qi Sun, Junfei Guo, Shixing Wang, Ge Song, Weiying Liu, Min Liu & Hua Tang
Pages: 668-685
Published online: 05 Nov 2018
AbstractforGRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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Research Paper - Basic Science

Article
HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells
Tanveer Sharif, Emma Martell, Cathleen Dai, Mohammad Saleh Ghassemi-Rad, Mark Robert Hanes, Patrick J. Murphy, Nandini N. Margam, Hirendrasinh B. Parmar, Carman A. Giacomantonio, Roy Duncan, Patrick W.K. Lee & Shashi Gujar
Pages: 686-706
Published online: 04 Dec 2018
AbstractforHDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
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Article
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells
Wei Hu, Lin Zhang, Ming Xing Li, Jing Shen, Xiao Dong Liu, Zhan Gang Xiao, Ding Lan Wu, Idy H. T. Ho, Justin C. Y. Wu, Cynthia K. Y. Cheung, Yu Chen Zhang, Alaster H. Y. Lau, Hassan Ashktorab, Duane T. Smoot, Evandro F. Fang, Matthew T. V. Chan, Tony Gin, Wei Gong, William K. K. Wu & Chi Hin Cho
Pages: 707-725
Published online: 06 Jan 2019
AbstractforVitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Commentary

Article Commentary
Negative-feedback coordination between proteasomal activity and autophagic flux
Jung Hoon Lee, Seoyoung Park, Eunkyoung Kim & Min Jae Lee
Pages: 726-728
Published online: 28 Jan 2019
AbstractforNegative-feedback coordination between proteasomal activity and autophagic flux | Full Text | References | PDF (512.1 KB) | EPUB
  • 1987 Views
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Article Commentary
Degradative autophagy selectively regulates CCND1 (cyclin D1) and MIR224, two oncogenic factors involved in hepatocellular carcinoma tumorigenesis
Shan-Ying Wu, Sheng-Hui Lan & Hsiao-Sheng Liu
Pages: 729-730
Published online: 31 Jan 2019
AbstractforDegradative autophagy selectively regulates CCND1 (cyclin D1) and MIR224, two oncogenic factors involved in hepatocellular carcinoma tumorigenesis | Full Text | References | PDF (346.2 KB) | EPUB
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Article Commentary
Autophagy promotes visceral aging in wild-type C. elegans
Alexandre Benedetto & David Gems
Pages: 731-732
Published online: 30 Jan 2019
AbstractforAutophagy promotes visceral aging in wild-type C. elegans | Full Text | References | PDF (530 KB) | EPUB
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Article Commentary
A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery
Hai-Ning Chen, Yan Chen, Zong-Guang Zhou, Yuquan Wei & Canhua Huang
Pages: 733-734
Published online: 22 Jan 2019
AbstractforA novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery | Full Text | References | PDF (342.8 KB) | EPUB
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Article Commentary
Mechanistic insight into the regulation of SQSTM1/p62
Yi Zhang, Su Ran Mun, Juan F. Linares, Christina G. Towers, Andrew Thorburn, Maria T. Diaz-Meco, Yong Tae Kwon & Tatiana G. Kutateladze
Pages: 735-737
Published online: 22 Jan 2019
AbstractforMechanistic insight into the regulation of SQSTM1/p62 | Full Text | References | PDF (703.7 KB) | EPUB
  • 2525 Views
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Article Commentary
A role for stromal autophagy in cancer-associated fibroblast activation
Sandro Goruppi, Andrea Clocchiatti & G. Paolo Dotto
Pages: 738-739
Published online: 22 Jan 2019
AbstractforA role for stromal autophagy in cancer-associated fibroblast activation | Full Text | References | PDF (537.5 KB) | EPUB
  • 2141 Views
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Article Commentary
Autophagy as a beacon and sentry for aging stem cells
Tanu Singh & Alana M. O’Reilly
Pages: 740-741
Published online: 22 Jan 2019
CitationforAutophagy as a beacon and sentry for aging stem cells | Full Text | References | PDF (252.9 KB) | EPUB
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Article Commentary
MTORC1 regulates autophagic membrane growth by targeting WIPI2
Wei Wan & Wei Liu
Pages: 742-743
Published online: 22 Jan 2019
AbstractforMTORC1 regulates autophagic membrane growth by targeting WIPI2 | Full Text | References | PDF (254.7 KB) | EPUB
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Article Commentary
DIABLO/SMAC mimetics selectively kill HIV-1-infected resting memory CD4+ T cells: a potential role in a cure strategy for HIV-1 infection
Grant R. Campbell & Stephen A. Spector
Pages: 744-746
Published online: 27 Jan 2019
AbstractforDIABLO/SMAC mimetics selectively kill HIV-1-infected resting memory CD4+ T cells: a potential role in a cure strategy for HIV-1 infection | Full Text | References | PDF (632.2 KB) | EPUB
  • 1977 Views
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Article Commentary
TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10
Peng Tan, Lian He & Yubin Zhou
Pages: 747-749
Published online: 22 Jan 2019
AbstractforTRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10 | Full Text | References | PDF (844.3 KB) | EPUB
  • 2189 Views
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Article Commentary
The Pat1-Lsm complex prevents 3′ to 5′ degradation of a specific subset of ATG mRNAs during nitrogen starvation-induced autophagy
Damián Gatica, Guowu Hu, Nannan Zhang, Peter R. Williamson & Daniel J. Klionsky
Pages: 750-751
Published online: 18 Mar 2019
AbstractforThe Pat1-Lsm complex prevents 3′ to 5′ degradation of a specific subset of ATG mRNAs during nitrogen starvation-induced autophagy | Full Text | References | PDF (360.5 KB) | EPUB
  • 912 Views
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