http://orcid.org/0000-0002-7828-8118
Figures & data
Figure 1. Two distinct pools of TORC1 regulate anabolic and catabolic processes. Amino acids simulate both the vacuolar pool and a novel endosomal pool of TORC1 via the small GTPases Gtr1 and Gtr2 (indicated by solid black arrows). Upon activation TORC1 (designated as ‘ON’) promotes general anabolism and protein synthesis while concomitantly downregulating degradative processes. The vacuolar pool of TORC1 is primarily involved in upregulating translation by phosphorylating the AGC-family kinase Sch9. The inhibition of degradative processes is largely mediated by the endosomal pool of TORC1 that phosphorylates Atg13 and Vps27 to inhibit macroautophagy and microautophagy, respectively (Adapted from [Citation16]).
![Figure 1. Two distinct pools of TORC1 regulate anabolic and catabolic processes. Amino acids simulate both the vacuolar pool and a novel endosomal pool of TORC1 via the small GTPases Gtr1 and Gtr2 (indicated by solid black arrows). Upon activation TORC1 (designated as ‘ON’) promotes general anabolism and protein synthesis while concomitantly downregulating degradative processes. The vacuolar pool of TORC1 is primarily involved in upregulating translation by phosphorylating the AGC-family kinase Sch9. The inhibition of degradative processes is largely mediated by the endosomal pool of TORC1 that phosphorylates Atg13 and Vps27 to inhibit macroautophagy and microautophagy, respectively (Adapted from [Citation16]).](/cms/asset/b99a354d-decb-4930-a611-66a7c5820629/kaup_a_1575162_f0001_oc.jpg)
