Figure 1. IPMK promotes AMPK activation and mediates deacetylation of histone K16 acetylation. It stimulates transcriptional activation of autophagic genes such as Lc3b, Bnip3, Bnip3l, Atg12, Sqstm1, and Gabarapl1. IPMK also forms a ternary complex of AMPK-IPMK-ULK. It facilitates AMPK-dependent ULK phosphorylation and activation of autophagy. Thus, IPMK could be a therapeutic target of autophagy-related diseases.
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