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Autophagy Volume 15, 2019 - Issue 8
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Autophagic Punctum

DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy

Anne Vehlowa OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany;b National Center for Tumor Diseases (NCT), Partner Site Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany;c German Cancer Consortium (DKTK), Partner Site Dresden, and DKFZ, Heidelberg, GermanyORCID Iconhttps://orcid.org/0000-0002-5381-0547View further author information
ORCID Icon &
Nils Cordesa OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany;d Helmholtz-Zentrum Dresden, Rossendorf, Institute of Radiooncology, OncoRay, Dresden, Germany;e University Hospital Carl Gustav Carus, Faculty of Medicine, Department of Radiation Oncology, Technische Universität Dresden, Dresden, Germany;c German Cancer Consortium (DKTK), Partner Site Dresden, and DKFZ, Heidelberg, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5684-629XView further author information
ORCID Icon
Pages 1487-1488 | Received 10 Apr 2019, Accepted 07 May 2019, Published online: 23 May 2019

Figures & data

Figure 1. Inhibition of DDR1 modulates radiosensitization through autophagy. Schematic representation of DDR1 function in GBM cells upon radiochemotherapy. Under basal conditions, DDR1 associates with YWHA/14–3-3-BECN1-AKT1 protein complex, mediates pro-survival DDR1 signaling and radiochemoresistance. Upon DDR1 inhibition, the YWHA/14–3-3-BECN1-AKT1 protein complex dissociates from DDR1. BECN1 interacts with PIK3C3/VPS34 and ATG14 and induces autophagic cell death forradiochemosensitization. P, phosphorylation.

Figure 1. Inhibition of DDR1 modulates radiosensitization through autophagy. Schematic representation of DDR1 function in GBM cells upon radiochemotherapy. Under basal conditions, DDR1 associates with YWHA/14–3-3-BECN1-AKT1 protein complex, mediates pro-survival DDR1 signaling and radiochemoresistance. Upon DDR1 inhibition, the YWHA/14–3-3-BECN1-AKT1 protein complex dissociates from DDR1. BECN1 interacts with PIK3C3/VPS34 and ATG14 and induces autophagic cell death forradiochemosensitization. P, phosphorylation.

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