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Autophagic Punctum

Bacterial outer membrane vesicles trigger pre-activation of a xenophagic response via AMPK

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Pages 1489-1491 | Received 21 Mar 2019, Accepted 16 Apr 2019, Published online: 23 May 2019

Figures & data

Figure 1. A diagram of AMPK signaling through ULK1 and PIK3C3/VPS34 complexes in response to Salmonella infection. (a) Upon detection of bacteria-secreted outer membrane vesicles, activated AMPK promotes upregulation of pro-autophagic kinases without inducing bulk autophagy. (b) Internalized bacteria are captured and targeted for xenophagic degradation.

Figure 1. A diagram of AMPK signaling through ULK1 and PIK3C3/VPS34 complexes in response to Salmonella infection. (a) Upon detection of bacteria-secreted outer membrane vesicles, activated AMPK promotes upregulation of pro-autophagic kinases without inducing bulk autophagy. (b) Internalized bacteria are captured and targeted for xenophagic degradation.

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