AMBRA1 has an impact on melanoma development beyond autophagy

Figures & data

Figure 1. Loss of Ambra1 promotes melanoma growth and metastasis independently of autophagy. For melanoma induction, ambra1^flox/flox mice were crossed with mice carrying the joint Braf^V600E substitution and pten deletion (Braf^V600E/+;pten^flox/flox), a genetic combination with 100% tumor penetrance in mice. When melanoma is formed, the absence of Ambra1 does not affect the autophagy flux in vivo. Instead, in vivo ablation of Ambra1 in melanoma results in boosted tumor growth and metastatic capacity by means of increased stability of CCND1 and enhanced activation of PTK2/FAK1 signaling, respectively